Fig. 4
A Correlation matrices illustrate the relationships between cortical lipid levels and clinical and AD neuropathology phenotypes, which are exaggerated in APOE4 carriers. Color-coded scale from -1.0 to 1.0 denotes the relative intensities of spearman correlation coefficients (rs). B Interaction effects between some of lipid mediator levels and APOE4 on global cognitive function (C) and neuritic plaque burden. Abbreviations: AA, arachidonic acid; 5-HETE, 5-hydroxyeicosatetraenoic acid; PGs, prostaglandins; TXB2, thromboxane B2; 12-HHT, 12-hydroxyheptadecatrienoic acid; LXs, lipoxins; LTB4, leukotriene B4; EPA, eicosapentaenoic acid; 5-HEPE, 5-hydroxyeicosapentaenoic acid; RvE3, resolvin E3; DHA, docosahexaenoic acid; 17-HDHA, 17-hydroxydocosahexaenoic acid; RvDs, D-series resolvins; NPD-1, neuroprotectin D1; DPA, docosapentaenoic acid; NFT, Neurofibrillary tangles. P values represent the interaction of APOE genotype and lipid mediators on global cognitive function and neuritic plaque burden