Imaging markers of cerebral amyloid angiopathy and hypertensive arteriopathy differentiate Alzheimer disease subtypes synergistically

Table 2 Correlations of singular imaging variables with neurocognitive domains, N = 137

Cognitive domain	CMB	Lacune	PV WMH	Deep WMH	WMH burden	BG PVSE	CSO PVSE	PVSE burden	Global SVD score	CAA-SVD score	HA-SVD score
Cognitive domain	β	β	β	β	β	β	β	β	β	β	β
MMSE	− .009	− .027	− .006	.015	.025	.017	.026	.064	− .064^*	− .044^**	− .115^**
MoCA	.094	.047	− .003	.020	.022	.017	.002	.034	.001	− .012	− .068^**
CDR-SB	.401	.122	.062	.023	.038	.013	.036	.012	.212^*	.043	.045
Orientation	− .047	− .011	− .038	.009	− .074	.101	− .073	− .070	− .173	− .054	− .297^**
Attention	.571	.027	− .060	.029	− .089	.024	− .002	.080	− .024	− .165	− .411^**
STM (registration)	− .431	.251	− .092	− .207^*	− .398	.001	− .105	.023	− .255	− .219^**	− .208
STM (recall)	− .304	.024	− .036	− .193^*	− .417	.005	.105	.168	− .232	− .009	− .021
Language	.188	.304	− .080	.048	.027	− .097	− .115	− .125	− .214	− .200^*	− .429^**
Visual execution	.463	.176	.006	.063	.321	.101	− .016	.117	.127	− .042	− .403^**

Linear regression, adjusted for age, sex, vascular risk factors, and CDR, was calculated to explore correlations between cognitive and imaging variable
Abbreviations: CMB cerebral microbleeds, PV periventricular, WMH white matter hyperintensity, BG basal ganglia, CSO centrum semiovale, PVSE perivascular space enlargement, SVD small vessel disease, CAA cerebral amyloid angiopathy, HA hypertensive arteriopathy, MMSE mini-mental state examination, MoCA Montreal Cognitive Assessment, CDR clinical dementia rating score, CDR-SB clinical dementia rating-sum of boxes, STM short-term memory
^*p < 0.05,
^**p < 0.01

ISSN: 1758-9193