From: Axonal degeneration and amyloid pathology predict cognitive decline beyond cortical atrophy
 | Included potential mediators | Path | Beta (95% CI) | Standardized beta (95% CI)a |
---|---|---|---|---|
Age | p-tau181, WML volume, NfL | Â | Â | Â |
 Direct effect |  |  | 0.003 (-0.018 to 0.026) |  |
 Total indirect effects |  |  | -0.010 (-0.022 to -0.0002) | -0.058 (-0.127 to -0.001) |
 Indirect effects |  | Age – P-tau181 – NfL – residual | -0.0006 (-0.002 to 0.0004) | -0.003 (-0.014 to 0.002) |
 |  | Age – NfL – residual | -0.007 (-0.016 to -0.001) | -0.043 (-0.094 to -0.009) |
 |  | Age – WML volume – NfL – residual | -0.002 (-0.004 to -0.0003) | -0.012 (-0.025 to -0.002) |
Male sex | WML volume, NfL | Â | Â | Â |
 Direct effect |  |  | 0.029 (-0.209 to 0.267) |  |
 Total indirect effect |  |  | -0.045 (-0.112 to 0.006) | -0.048 (-0.120 to 0.006) |
 Indirect effects |  | Sex – NfL – residual | -0.050 (-0.116 to -0.006) | -0.054 (-0.125 to -0.007) |
 |  | Sex – WML volume – NfL – residual | 0.006 (-0.001 to 0.017) | 0.006 (-0.002 to 0.018) |
WML volume | NfL | Â | Â | Â |
 Direct effect |  |  | 0.004 (-0.172 to 0.181) |  |
 Total indirect effect |  |  | -0.049 (-0.101 to -0.009) | -0.034 (-0.070 to -0.006) |
 Indirect effects |  | WML volume – NfL – residual | -0.049 (-0.101 to -0.009) | -0.034 (-0.070 to -0.006) |
APOEe4 allele | Aβ42/40b, GFAP, P-tau181, NfL |  |  |  |
 Direct effect |  |  | -0.067 (-0.285 to 0.152) |  |
 Total indirect effect |  |  | -0.173 (-0.315 to -0.051) | -0.184 (-0.324 to -0.057) |
 Indirect effects |  | APOE4 – Aβ42/40 – GFAP – P-tau181 – NfL – residual | -0.0038 (-0.0087 to -0.0005) | -0.0041 (-0.010 to -0.0006) |
 |  | APOE4 – Aβ42/40 – GFAP – NfL – residual | -0.0069 (-0.0164 to -0.001) | -0.0074-(-0.0174 to -0.0011) |
 |  | APOE4 – Aβ42/40 – P-tau181 – NfL – residual | -0.0237 (-0.050 to -0.006) | -0.025 (-0.054 to -0.006) |
 |  | APOE4 – Aβ42/40 – NfL – residual | 0.004 (-0.016 to 0.034) | 0.004 (-0.018 to 0.037) |
 |  | APOE4 – Aβ42/40 – residual | -0.129 (-0.315 to -0.051) | -0.137 (-0.268 to -0.021) |