Fig. 7
Nanoscale organization of GABAB receptors and GIRK2 channels in the hippocampus of wild type and APP/PS1. A Nearest neighbour distances (NNDs) between the 10-nm gold particles (GABAB1) and the 5-nm immunoparticles (GIRK2) were measured in spines and oblique dendrites (oDen) using the GPDQ software. The distances (median values) between immunoparticles for GIRK2 and GABAB1 are shorter in the wild type than in APP/PS1 mice, both in spines and oblique dendrites (oDen) of CA1 pyramidal cells (****p < 0.0001, Mann–Whitney U test). B We compared NNDs from real and simulated GIRK2 particles to real GABAB1 immunoparticles in dendritic shafts and spines, showing significantly larger NNDs for the randomly distributed GIRK2 immunoparticles compared to the real distributions (**p < 0.01, **** p < 0.0001, Mann–Whitney U test)