Table 5 Cross-tissue analysis of female samples prioritized a total of 25 significant CpGs. (a) A total of 13 CpGs reached a P-value < 10−5 in cross-tissue meta-analyses that included both brain and blood samples, and nominal significance (i.e., P-value < 0.05) in sex-specific meta-analyses of each tissue. The brain sample meta-analysis results were obtained from Zhang et al. [36]; (b) A total of 4 CpGs achieved P-value < 10-5 in blood sample meta-analysis and nominal significance in brain sample meta-analysis; (c) A total of 13 CpGs achieved P-value < 10-5 in brain sample meta-analysis and nominal significance in blood sample meta-analysis. Direction indicates hypermethylation (+) or hypomethylation (-) in AD samples in individual brain or blood sample datasets. Annotations include nearby genes based on GREAT annotation and overlap with enhancer regions identified in the Nasser et al. [53] study. All but 5 significant CpG showed the same direction of change in brain and blood samples (highlighted in gray). Highlighted in red are gene promoter regions overlapped with the significant CpGs
From: Distinct sex-specific DNA methylation differences in Alzheimer’s disease
