Fig. 2

Schematic illustration of the mediation analyses investigating the link between SCD and anxiety/depression scores. Regression coefficients for paths a, b, c, c′, and ab are reported in the figure. The total effect of SCD-Q MyCog on HADS (path c) is shown as the summation of the direct effect adjusted by the given mediator (c′) and the indirect effect (ab). The analyses were adjusted by age, sex, years of education, pre-confinement HADS scores, and time difference between the pre-confinement and confinement assessments. *p < 0.05, **p < 0.01, ***p < 0.001. A The results of the mediation analysis investigating the role of PSS as a mediator between SCD-Q MyCog scores and HADS scores. The indirect effect (path ab) was statistically significant (p = 0.01) corresponding to 63% of the total association between the two variables. B The results of the mediation analysis investigating the role of Aβ as a mediator between SCD-Q MyCog and HADS scores. The indirect effect (path ab) did not show a statistically significant effect (p = 0.45). Abbreviations: SCD-Q, Subjective Cognitive Decline Questionnaire; PSS, Perceived Stress Scale; HADS, Hospital Anxiety and Depression Scale; Aβ, amyloid-beta; CL, Centiloid