Evaluation of tau deposition using 18F-PI-2620 PET in MCI and early AD subjects—a MissionAD tau sub-study

Table 2 Regional ¹⁸F-PI-2620 SUVR (mean±SD [minimum, maximum]) by amyloid-beta group

Centiloid	< 36	36-83	p¹	>83	p²	p³	p⁴
Mesial temporal	1.04±0.07 [0.88, 1.16]	1.13±0.19 [0.91, 1.86]	0.28	1.32±0.21 [0.96, 1.77]	0.0006	0.00006	< 0.0001
Fusiform gyrus	1.11±0.19 [0.92, 1.71]	1.22±0.21 [1.01, 2.01]	0.39	1.43±0.32 [0.99, 2.17]	0.008	0.001	0.0005
Inferior temporal	1.08±0.15 [0.92, 1.53]	1.19±0.24 [1.00, 2.27]	0.60	1.45±0.41 [0.89, 2.43]	0.004	0.002	0.0005
Superior temporal	0.93±0.08 [0.78, 1.08]	1.00±0.16 [0.79, 1.65]	0.68	1.16±0.32 [0.82, 2.11]	0.02	0.01	0.004
Occipital	1.10±0.10 [0.92, 1.27]	1.13±0.13 [0.97, 1.54]	0.84	1.22±0.19 [0.9, 1.75]	0.05	0.05	0.02
Parietal	1.01±0.11 [0.8, 1.29]	1.06±0.26 [0.83, 2.31]	0.84	1.17±0.3 [0.88, 2.17]	0.26	0.18	0.13

CL¹⁸F-florbetaben centiloid, SUVR standardized uptake value ratio, SD standard deviation, p¹, p², and p³p-values obtained from Tukey’s honestly significant difference test comparing <36 vs 36–83, 36–83 vs >82, and <36 vs >83, respectively, p⁴p-values obtained using the analysis of variance (ANOVA) to compare the mean ¹⁸F-PI-2620 SUVR in different amyloid-beta levels

ISSN: 1758-9193