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Table 2 Regional 18F-PI-2620 SUVR (mean±SD [minimum, maximum]) by amyloid-beta group

From: Evaluation of tau deposition using 18F-PI-2620 PET in MCI and early AD subjects—a MissionAD tau sub-study

Centiloid < 36 36-83 p1 >83 p2 p3 p4
Mesial temporal 1.04±0.07 [0.88, 1.16] 1.13±0.19 [0.91, 1.86] 0.28 1.32±0.21 [0.96, 1.77] 0.0006 0.00006 < 0.0001
Fusiform gyrus 1.11±0.19 [0.92, 1.71] 1.22±0.21 [1.01, 2.01] 0.39 1.43±0.32 [0.99, 2.17] 0.008 0.001 0.0005
Inferior temporal 1.08±0.15 [0.92, 1.53] 1.19±0.24 [1.00, 2.27] 0.60 1.45±0.41 [0.89, 2.43] 0.004 0.002 0.0005
Superior temporal 0.93±0.08 [0.78, 1.08] 1.00±0.16 [0.79, 1.65] 0.68 1.16±0.32 [0.82, 2.11] 0.02 0.01 0.004
Occipital 1.10±0.10 [0.92, 1.27] 1.13±0.13 [0.97, 1.54] 0.84 1.22±0.19 [0.9, 1.75] 0.05 0.05 0.02
Parietal 1.01±0.11 [0.8, 1.29] 1.06±0.26 [0.83, 2.31] 0.84 1.17±0.3 [0.88, 2.17] 0.26 0.18 0.13
  1. CL18F-florbetaben centiloid, SUVR standardized uptake value ratio, SD standard deviation, p1, p2, and p3p-values obtained from Tukey’s honestly significant difference test comparing <36 vs 36–83, 36–83 vs >82, and <36 vs >83, respectively, p4p-values obtained using the analysis of variance (ANOVA) to compare the mean 18F-PI-2620 SUVR in different amyloid-beta levels