Evaluation of tau deposition using 18F-PI-2620 PET in MCI and early AD subjects—a MissionAD tau sub-study

Table 1 Demographic characteristics of the study participants

	Baseline dataset	Subset with longitudinal cognitive information	p¹	Subset with longitudinal PET scans	p²
n	74	36		15
Age (years)	75.78 ± 6.61 (54, 85)	75.69±7.13 [55, 85]	N.S	75.33 ± 8.92 (57, 85)	N.S
Sex	36 (48.6%) M	17 (47.2%) (M)	N.S	8 (53.3%) M	N.S
Sex	38 (51.4%) F	19 (52.8%) (F)		7 (46.7%) F
Clinical diagnosis	72 (MCI due to AD)	34 (MCI due to AD)	N.S	14 (MCI due to AD)	N.S
Clinical diagnosis	2 (mild AD)	2 (mild AD)		1 (Mild AD)
MMSE	26.51 ± 2.5 (20, 30)	26.31±2.56 [21, 30]	N.S	26.93 ± 2.41 (21, 30)	N.S
CDR-SB	2.35 ± 1.04 (0.5, 5)	2.51±1.1 [0.5, 5]	N.S	2.47 ± 0.79 (1, 4)	N.S
CL	71.64±40.07 (−13.39, 181.87)	71.81±36.14 [7.2, 154.75]	N.S	62.16±41.46 (7.2, 154.75)	N.S
SUVR (PI-2620)	1.28±0.35 [0.89, 2.43]	1.31±0.39 [0.89, 2.43]	N.S	1.1±0.17 [0.89, 1.65]	p=0.01

MCI mild cognitive impairment, AD Alzheimer’s disease, MMSE Mini-Mental State Examination, CDR-SB Clinical dementia rating – Sum of boxes, CL (¹⁸F-florbetaben) centiloid at baseline, SUVR(¹⁸F-PI-2620) Standardized uptake value for ¹⁸F-PI-2620 scans at baseline in the inferior temporal cortex, p¹p-values comparing the demographic characteristics between the subset of subjects with longitudinal cognitive information and the remaining subjects from the baseline dataset (Wilcoxon rank sum (continuous variables) test and chi-squared test (categorical variables)), p²p-values comparing the demographic characteristics between the subset of subjects with longitudinal ¹⁸F-PI-2620 scans and the remaining subjects from the baseline dataset (Wilcoxon rank sum test (continuous variables) and chi-squared test (categorical variables)), N.S non-significant differences (p>0.05)

ISSN: 1758-9193