Skip to main content

Table 1 Demographic characteristics of the study participants

From: Evaluation of tau deposition using 18F-PI-2620 PET in MCI and early AD subjects—a MissionAD tau sub-study

  Baseline dataset Subset with longitudinal cognitive information p1 Subset with longitudinal PET scans p2
n 74 36   15  
Age (years) 75.78 ± 6.61 (54, 85) 75.69±7.13 [55, 85] N.S 75.33 ± 8.92 (57, 85) N.S
Sex 36 (48.6%) M 17 (47.2%) (M) N.S 8 (53.3%) M N.S
38 (51.4%) F 19 (52.8%) (F)   7 (46.7%) F  
Clinical diagnosis 72 (MCI due to AD) 34 (MCI due to AD) N.S 14 (MCI due to AD) N.S
2 (mild AD) 2 (mild AD)   1 (Mild AD)  
MMSE 26.51 ± 2.5 (20, 30) 26.31±2.56 [21, 30] N.S 26.93 ± 2.41 (21, 30) N.S
CDR-SB 2.35 ± 1.04 (0.5, 5) 2.51±1.1 [0.5, 5] N.S 2.47 ± 0.79 (1, 4) N.S
CL 71.64±40.07 (−13.39, 181.87) 71.81±36.14 [7.2, 154.75] N.S 62.16±41.46 (7.2, 154.75) N.S
SUVR (PI-2620) 1.28±0.35 [0.89, 2.43] 1.31±0.39 [0.89, 2.43] N.S 1.1±0.17 [0.89, 1.65] p=0.01
  1. MCI mild cognitive impairment, AD Alzheimer’s disease, MMSE Mini-Mental State Examination, CDR-SB Clinical dementia rating – Sum of boxes, CL (18F-florbetaben) centiloid at baseline, SUVR(18F-PI-2620) Standardized uptake value for 18F-PI-2620 scans at baseline in the inferior temporal cortex, p1p-values comparing the demographic characteristics between the subset of subjects with longitudinal cognitive information and the remaining subjects from the baseline dataset (Wilcoxon rank sum (continuous variables) test and chi-squared test (categorical variables)), p2p-values comparing the demographic characteristics between the subset of subjects with longitudinal 18F-PI-2620 scans and the remaining subjects from the baseline dataset (Wilcoxon rank sum test (continuous variables) and chi-squared test (categorical variables)), N.S non-significant differences (p>0.05)