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Table 3 Correlations of the neuronal pentraxins with brain volumes derived from structural T1-weighted MR imaging (total brain as well as frontal, temporal, and parietal cortical volumes), NfL (plasma neurofilament light chain concentration), and CDR plus NACC FTLD sum of boxes score

From: Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia

  

Presymptomatic C9orf72

Symptomatic C9orf72

Presymptomatic

GRN

Symptomatic GRN

Presymptomatic MAPT

Symptomatic MAPT

Rho

p-value

Rho

p-value

Rho

p-value

Rho

p-value

Rho

p-value

Rho

p-value

NPTXR NNYMYAR

Total brain

0.42

0.025

0.23

0.365

0.14

0.532

0.48

0.161

0.24

0.303

0.66

0.157

Frontal

0.19

0.321

0.41

0.090

0.53

0.011

0.73

0.017

0.15

0.522

0.81

0.053

Temporal

0.50

0.006

0.14

0.588

0.30

0.182

0.77

0.009

 − 0.06

0.810

0.30

0.564

Parietal

0.11

0.571

0.10

0.704

0.52

0.014

0.51

0.131

0.17

0.483

0.64

0.170

NfL

0.00

0.994

 − 0.68

0.005

0.02

0.925

0.08

0.821

 − 0.14

0.572

0.94

0.016

CDR plus NACC FTLD

 − 0.38

0.044

 − 0.29

0.248

0.00

0.997

 − 0.28

0.425

0.19

0.422

 − 0.21

0.697

NPTX1 CESQSTLDPGAGEAR

Total brain

0.36

0.052

0.11

0.654

0.34

0.118

0.17

0.633

0.23

0.327

0.40

0.427

Frontal lobe

0.25

0.183

0.06

0.812

0.52

0.012

0.42

0.225

0.00

0.996

0.54

0.264

Temporal lobe

0.20

0.300

 − 0.05

0.833

0.41

0.058

0.40

0.255

 − 0.09

0.711

0.01

0.984

Parietal lobe

0.41

0.029

 − 0.24

0.345

0.59

0.004

0.44

0.205

0.08

0.740

0.50

0.315

NfL

0.04

0.856

 − 0.51

0.051

0.07

0.757

 − 0.22

0.539

 − 0.46

0.040

0.54

0.348

CDR plus NACC FTLD

0.10

0.601

 − 0.07

0.770

 − 0.12

0.593

0.06

0.870

 − 0.01

0.961

 − 0.45

0.373

NPTX2 VAELEDEK

Total brain

0.38

0.045

0.38

0.120

0.25

0.257

0.50

0.145

0.31

0.189

0.95

0.004

Frontal lobe

0.21

0.277

0.60

0.008

0.41

0.059

0.80

0.006

0.16

0.489

0.80

0.054

Temporal lobe

0.49

0.007

0.42

0.080

0.20

0.377

0.65

0.043

0.12

0.623

0.75

0.085

Parietal lobe

0.18

0.343

0.27

0.274

0.45

0.035

0.50

0.141

0.11

0.657

0.67

0.148

NfL

0.05

0.786

 − 0.48

0.073

0.06

0.781

 − 0.08

0.837

 − 0.03

0.886

0.67

0.215

CDR plus NACC FTLD

 − 0.37

0.048

 − 0.49

0.041

0.00

0.989

 − 0.24

0.497

0.18

0.436

 − 0.60

0.204