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Table 1 Demographic data of post-mortem brain samples

From: YKL-40 changes are not detected in post-mortem brain of patients with Alzheimer’s disease and frontotemporal lobar degeneration

  Temporal cortex Frontal cortex
Technology CON AD CON AD FTLD
IHC
n (M/F) 51 (19/32) 56 (16/40) 7 (4/3) - 24 (11/13)
 Age, years (mean ± SD) 79 (12) 81 (10) 70 (10) - 68 (10)
 PMD, hours (mean ± SD) 6 (3) 5 (1) 5 (4) - 6 (2)
 FTLD subgroups      
  FTLD-Tau      4 PSP, 1 CBD, 6 PiD, 8 MAPT
  FTLD-TDP      5 TDP pathology
WB/ELISA$      
n (M/F) 11 (2/9) 7 (4/3) 14 (8/6) 5 (5/0) 67 (32/35)
 Age, years (mean ± SD) 72 (12) 76 (8) 67 (9) A 80 (11)B, C 67 (9)A
 PMD, hours (mean ± SD) 6 (3) 6 (1) 7 (3) 5 (1) 8 (6)
 FTLD Subgroups      
  FTLD-Tau      11 PSP, 3 CBD, 3 PiD, 16 MAPT
  FTLD-TDP      21 TDP pathology, 7 C9orf72, 6 GRN
  1. CON, non-demented controls; AD, Alzheimer’s disease; FTLD, frontotemporal lobar degeneration; TDP, TAR DNA-binding protein; PiD, Pick disease; PSP, progressive supranuclear palsy; CBD, corticobasal degeneration; n, number of cases; M, male; F, female; PMD, post-mortem delay; IHC, immunohistochemistry; WB, western blot; ELISA, enzyme-linked immuno sorbent assay
  2. P<0.05 from (A) AD, (B) CON, or (C) FTLD group
  3. $ indicates Con and AD temporal cortex tissue that was analyzed only by ELISA due to limited availability