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Table 1 Demographic data of post-mortem brain samples

From: YKL-40 changes are not detected in post-mortem brain of patients with Alzheimer’s disease and frontotemporal lobar degeneration

 

Temporal cortex

Frontal cortex

Technology

CON

AD

CON

AD

FTLD

IHC

n (M/F)

51 (19/32)

56 (16/40)

7 (4/3)

-

24 (11/13)

 Age, years (mean ± SD)

79 (12)

81 (10)

70 (10)

-

68 (10)

 PMD, hours (mean ± SD)

6 (3)

5 (1)

5 (4)

-

6 (2)

 FTLD subgroups

     

  FTLD-Tau

    

4 PSP, 1 CBD, 6 PiD, 8 MAPT

  FTLD-TDP

    

5 TDP pathology

WB/ELISA$

     

n (M/F)

11 (2/9)

7 (4/3)

14 (8/6)

5 (5/0)

67 (32/35)

 Age, years (mean ± SD)

72 (12)

76 (8)

67 (9) A

80 (11)B, C

67 (9)A

 PMD, hours (mean ± SD)

6 (3)

6 (1)

7 (3)

5 (1)

8 (6)

 FTLD Subgroups

     

  FTLD-Tau

    

11 PSP, 3 CBD, 3 PiD, 16 MAPT

  FTLD-TDP

    

21 TDP pathology, 7 C9orf72, 6 GRN

  1. CON, non-demented controls; AD, Alzheimer’s disease; FTLD, frontotemporal lobar degeneration; TDP, TAR DNA-binding protein; PiD, Pick disease; PSP, progressive supranuclear palsy; CBD, corticobasal degeneration; n, number of cases; M, male; F, female; PMD, post-mortem delay; IHC, immunohistochemistry; WB, western blot; ELISA, enzyme-linked immuno sorbent assay
  2. P<0.05 from (A) AD, (B) CON, or (C) FTLD group
  3. $ indicates Con and AD temporal cortex tissue that was analyzed only by ELISA due to limited availability