Table 5 Differences in protein levels between p-tau subgroups in amyloid-negative CN individuals
From: P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles
Protein (n) | Protein level per group: estimate ± standard error of the mean (SE) | Differences between p-tau subgroups: mean ± SE | p-values of contrasts | ||||||
|---|---|---|---|---|---|---|---|---|---|
Subgroup 1: p-tau ≤ 56 pg/ml (n = 103) | Subgroup 2: p-tau 57–96 pg/ml (n = 7) | Subgroup 3: p-tau 97–159 pg/ml (n = 2) | 2 vs 1 | 3 vs 1 | 3 vs 2 | 2 vs 1 | 3 vs 1 | 3 vs 2 | |
Core AD biomarker | |||||||||
Aβ42 (n = 112) | 0.04 ± 0.11 | 0.61 ± 0.39 | − 0.01 ± 0.74 | 0.56 ± 0.41 | − 0.05 ± 0.74 | − 0.62 ± 0.83 | 0.427 | 1.000 | 0.843 |
Analytes | |||||||||
BACE1 (n = 112) | 0.03 ± 0.1 | 1.44 ± 0.37 | 2.71 ± 0.69 | 1.4 ± 0.38 | 2.68 ± 0.69 | 1.28 ± 0.78 | 1.02E−03 | 5.61E−04 | 0.276 |
Aβ40 (n = 112) | 0.1 ± 0.1 | 1.55 ± 0.36 | 2.3 ± 0.69 | 1.45 ± 0.38 | 2.2 ± 0.69 | 0.75 ± 0.77 | 6.24E−04 | 5.54E−03 | 0.701 |
NfL (n = 111) | − 0.07 ± 0.09 | 0.36 ± 0.31 | 0.34 ± 0.59 | 0.42 ± 0.32 | 0.41 ± 0.59 | − 0.02 ± 0.66 | 0.470 | 0.869 | 1.000 |
VAMP2 (n = 105) | 0.07 ± 0.11 | 1.4 ± 0.38 | 2.3 ± 0.72 | 1.33 ± 0.39 | 2.23 ± 0.72 | 0.9 ± 0.8 | 3.16E−03 | 7.51E−03 | 0.604 |
NRGN (n = 112) | 0.09 ± 0.1 | 1.37 ± 0.38 | 2.88 ± 0.71 | 1.29 ± 0.39 | 2.79 ± 0.72 | 1.5 ± 0.8 | 4.25E−03 | 5.29E−04 | 0.180 |