Table 3 Comparison of clinical features between gPrD patients with FTD phenotype and FTD/prion disease
Variables | GPrDs presenting as FTD (N = 49) | FTD (N = 51) | Prion diseases (N = 136) | P valuesa | P valuesb |
|---|---|---|---|---|---|
Clinical features of FTD | |||||
 Disinhibition, % | 23/40 (57.5) | 26 (51.0) | 11 (8.1) | 0.536 | < 0.001 |
 Apathy, % | 27/42 (64.3) | 35 (68.7) | 28 (20.6) | 0.658 | < 0.001 |
 Loss of empathy, % | 8/40 (20.0) | 28 (54.9) | 15 (11.0) | 0.001 | 0.139 |
 Stereotyped/perseverative behavior, % | 16/40 (40.0) | 33 (64.7) | 10 (7.4) | 0.019 | < 0.001 |
 Alterations in food preferences, % | 10/40 (25.0) | 10 (19.6) | 5 (3.7) | 0.538 | < 0.001 |
 Executive deficits, % | 23/40 (57.5) | 27 (52.9) | 23 (16.9) | 0.664 | < 0.001 |
 Speech disorders, % | 23/29 (79.3) | 27 (52.9) | 84 (61.8) | 0.019 | 0.072 |
Clinical features of prion diseases | |||||
 Cognitive dysfunction, % | 38/41 (92.7) | 45 (88.2) | 104 (76.5) | 0.475 | 0.022 |
 Parkinsonism, % | 28/44 (63.7) | 5 (9.8) | 63 (46.3) | < 0.001 | 0.046 |
 Pyramidal signs, % | 9/23 (39.1) | 4 (7.8) | 70 (51.5) | 0.001 | 0.274 |
 Mutism, % | 14/39 (35.9) | 0 | 14 (10.3) | < 0.001 | < 0.001 |
 Visual signs, % | 5/21 (23.8) | 6 (11.8) | 48 (35.3) | 0.197 | 0.300 |
 Seizure, % | 8/31 (25.8) | 0 | 9 (6.6) | < 0.001 | 0.001 |
 Cerebellar signs, % | 7/31 (22.6) | 5 (5.9) | 73 (53.7) | 0.112 | 0.003 |
 Myoclonus, % | 9/40 (22.5) | 0 | 56 (41.2) | < 0.001 | 0.031 |