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Table 1 Main features of published clinical studies using voxel-based analysis comparing SCD with HC: sample characteristics, study type and outcomes

From: Grey matter changes on brain MRI in subjective cognitive decline: a systematic review

Reference Sample Age Sample recruitment Study type Main results
Control SCI Control SCI
Chételat et al. (2010) [16, 17] 45 49 74.9 (7.1) 73.9 (7.2) Other Prospective Regional atrophy was found in the bilateral superior frontal sulci in SCD compared with HC.
Choi et al. (2015) [18] 33 36 63.9 (7.5) 64.6 (7.7) Memory clinic Retrospective Regional atrophy was found in the left superior and medial frontal gyri, left superior and inferior parietal lobules and right precuneus and insula in SCD compared with HC.
Dong et al. (2020) [19] 67 63 65.3 (5.1) 65.8(5.0) Other Retrospective No significant differences were found between SCD and HC.
Erk et al. (2011) [20] 20 19 66.8 (5.4) 68.4 (5.7) Memory clinic Retrospective No significant differences were found between SCD and HC.
Hafkemeijer (2013) [21, 22] 29 25 71.3 (3.4) 71.4 (9.2) Memory clinic Prospective Regional atrophy was found in the right hippocampus and amygdala, bilateral ACC, mPFC, cuneus, precuneus and precentral gyrus in SCD compared with HC.
Hong et al. (2015) [23] 28 28 70.6 (6.48) 70.9 (6.23) Memory clinic Prospective Regional atrophy was found in the left orbitofrontal gyrus, inferior frontal gyrus, right calcarine gyrus, precuneus, lingual gyrus, inferior temporal gyrus and other mid-cingulate areas in SCD compared with HC.
Kiuchi et al. (2014) [11] 41 28 75.2 (5.3) 70.5 (7.3) Memory clinic Prospective No significant differences were found between SCD and HC.
Liang et al. (2020) [24] 32 35 63.03 (5.4) 64.94 (5.95) Other Prospective Regional atrophy was found in the bilateral hippocampal tails and increased volume was found in the bilateral paracentral lobules in SCD compared with HC.
Parker et al. (2020) [25] 23 23 74.3 (5.0) 72.9 (5.4) Other Retrospective No significant differences were found between SCD and HC.
Perrotin et al. (2015) [26] 40 17 69.35 (6.37) 69.12 (8.52) Memory clinic Prospective Regional atrophy was found in the hippocampus (CA1) in SCD compared with HC.
Perrotin et al. (2017) [12] 35 63 65.6 (8.6) 67.6 (7.7)*
70.8 (7.5)*
Other Prospective No significant differences were found between SCD and HC.
Saykin et al. (2006) [27] 40 40 71 (5.1) 73.3 (6) Other Prospective Regional atrophy was found in the bilateral frontal lobe (top), right hippocampus (middle) and left hippocampus in SCD compared with HC.
Scheef et al. (2012) [28] 56 31 66.4 (7.2) 67.6 (6.2) Memory clinic Prospective Regional atrophy was found in the right hippocampus in SCD compared with HC.
Sun et al. (2016) [29] 61 25 64.11 (8.59) 65.52 (6.12) Memory clinic Prospective No significant differences were found between SCD and HC.
Xue et al. (2020) [30] 28 19 72.66 (4.42) 71.95 (5.09) Other Retrospective No significant differences were found between SCD and HC.
  1. Bold text indicates the studies that found statistical differences between SCD and HC participants. *Data correspond to SCDclinic and SCDcommunity groups, respectively. Abbreviations: HC Healthy control, SCD subjective cognitive decline, ACC anterior cingulate cortex, mPFC medial prefrontal cortex