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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia

Fig. 1

Associations of age with A global normalized white matter hyperintensity volume (WMH) in PSEN1 E280A mutation carriers and non-carriers; B relative differences in lobe-specific normalized WMH volume in PSEN1 E280A mutation carriers; C relative differences across quantified biomarkers in PSEN1 E280A mutation carriers. All regression curves were fitted with a quadratic model and the 95% confidence intervals. In plots B and C, Z-scores reflecting relative differences were obtained using the mean of non-carrier individuals. Cortical amyloid (PET), measure of global cortical amyloid accumulation from positron emission tomography (PET) expressed in standardized uptake value ratio (SUVR); CSF, cerebrospinal fluid; ptau, phospho-tau; Aβ, amyloid-beta; SPL CT, superior parietal lobe cortical thickness; nWMH, normalized white matter hyperintensity volume. The dashed vertical line represents the median age of symptom onset in this clinical sample (i.e., 44 years) and the two vertical dotted lines represent 95% confidence intervals (i.e., 95% C.I. = 43, 45 years)

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Alzheimer's Research & Therapy

ISSN: 1758-9193