Table 1 Characteristics of participants across LS7 categories

N

128

852

126

1106

–

Age (years), mean (SD)

62.12 (9.74)

62.89 (10.15)

58.84 (10.96)

62.34 (10.27)

.0002^a

Gender, female (%)

44 (34.37)

334 (39.20)

60 (47.61)

438 (39.60)

.0861^b

Education (years), mean (SD)

9.35 (4.33)

9.61 (4.21)

10.90 (3.83)

9.73 (4.20)

.0031^a

APOE ε4, yes (%)

19 (16.10)

104 (13.79)

14 (12.50)

137 (13.92)

.7163^b

CM-MMSE, mean (SD)

27.85 (2.26)

27.90 (2.06)

28.33 (1.77)

27.94 (2.05)

.0942^c

LS7 score, mean (SD)

4.47 (0.78)

8.01 (1.28)

11.44 (0.70)

7.99 (2.05)

 < .0001^a

CSF AD biomarkers

 Abeta42, mean (SD)

187.19 (97.19)

202.61 (112.61)

182.53 (91.32)

198.64 (108.95)

.1920^a

 AbetA40, mean (SD)

6116.46 (2834.65)

5880.47 (2650.43)

5014.28 (2349.72)

5808.7 (2653.89)

.0015^a

 Abeta42/40, mean (SD)

0.0401 (0.0423)

0.0404 (0.0289)

0.0411 (0.0213)

0.0404 (0.0300)

.2090^a

 P-TAU181, mean (SD)

38.46 (10.45)

37.68 (9.30)

34.25 (6.95)

37.36 (9.26)

.0005^a

 T-TAU, mean (SD)

183.77 (78.51)

177.72 (83.35)

149.44 (65.18)

175.21 (81.43)

.0001^a