| | |
Total participants
|
Aβ− NCs
|
Aβ+ NCs
|
aMCI plus ADD
|
|---|
|
L_temporal lobe
|
R
|
0.4618
|
0.0490
|
0.4178
|
0.2751
|
|
p
|
0.0000
|
0.6678
|
0.0005
|
0.2544
|
|
R_temporal lobe
|
R
|
0.5493
|
0.0770
|
0.5383
|
0.5156
|
|
p
|
0.0000
|
0.5000
|
0.0000
|
0.0239
|
|
L_parietal lobe
|
R
|
0.5699
|
0.0332
|
0.4662
|
0.6309
|
|
p
|
0.0000
|
0.7715
|
0.0001
|
0.0038
|
|
R_parietal lobe
|
R
|
0.6029
|
0.1266
|
0.4573
|
0.7577
|
|
p
|
0.0000
|
0.2662
|
0.0001
|
0.0002
|
|
L_frontal lobe
|
R
|
0.5808
|
0.0815
|
0.5514
|
0.7901
|
|
p
|
0.0000
|
0.4751
|
0.0000
|
0.0001
|
|
R_frontal lobe
|
R
|
0.6043
|
0.1555
|
0.5214
|
0.7979
|
|
p
|
0.0000
|
0.1713
|
0.0000
|
0.0000
|
|
L_Pre
|
R
|
0.5492
|
− 0.0356
|
0.4839
|
0.4321
|
|
p
|
0.0000
|
0.7558
|
0.0000
|
0.0647
|
|
R_Pre
|
R
|
0.5359
|
− 0.0051
|
0.4701
|
0.4264
|
|
p
|
0.0000
|
0.9645
|
0.0001
|
0.0687
|
|
L_ACC
|
R
|
0.5396
|
− 0.0318
|
0.5702
|
0.2565
|
|
p
|
0.0000
|
0.7812
|
0.0000
|
0.2891
|
|
R_ACC
|
R
|
0.5074
|
0.0570
|
0.5480
|
0.3642
|
|
p
|
0.0000
|
0.6181
|
0.0000
|
0.1253
|
|
L_PCC
|
R
|
0.4744
|
0.0901
|
0.4891
|
0.3325
|
|
p
|
0.0000
|
0.4299
|
0.0000
|
0.1643
|
|
R_PCC
|
R
|
0.2522
|
0.0292
|
0.0430
|
0.2076
|
|
p
|
0.0009
|
0.7983
|
0.7317
|
0.3938
|
|
L_Ent
|
R
|
0.4441
|
− 0.0206
|
0.3807
|
0.3183
|
|
p
|
0.0000
|
0.8571
|
0.0016
|
0.1841
|
|
R_Ent
|
R
|
0.4927
|
0.0240
|
0.4267
|
0.5008
|
|
p
|
0.0000
|
0.8334
|
0.0004
|
0.0290
|
|
L_HP
|
R
|
0.0344
|
0.0007
|
− 0.2287
|
0.2958
|
|
p
|
0.6563
|
0.9953
|
0.0647
|
0.2188
|
|
R_HP
|
R
|
0.0599
|
− 0.0455
|
− 0.1864
|
0.2974
|
|
p
|
0.4377
|
0.6904
|
0.1339
|
0.2162
|
- The partial correlation analyses between nEV Aβ42 and regional AV45 SUVR were performed in all participants (n = 179), Aβ− NCs (n = 84), Aβ+ NCs (n = 72), and aMCI plus ADD individuals (n = 23), with correction for age, sex, and APOE ε4 status; the correlation coefficients and p values are listed
- Abbreviations: Aβ β-amyloid, NCs cognitively normal controls, aMCI amnestic mild cognitive impairment, ADD Alzheimer’s disease dementia, APOE apolipoprotein E, nEV neuronal-derived extracellular vesicle, AV45 [18F]florbetapir, SUVR standardized uptake value ratio, Pre precuneus, ACC anterior cingulate cortex, PCC posterior cingulate cortex, Ent entorhinal cortex, HP hippocampus
