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Table 4 Relationships between nEV Aβ42 and regional AV45 SUVR

From: β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

   Total participants Aβ− NCs Aβ+ NCs aMCI plus ADD
L_temporal lobe R 0.4618 0.0490 0.4178 0.2751
p 0.0000 0.6678 0.0005 0.2544
R_temporal lobe R 0.5493 0.0770 0.5383 0.5156
p 0.0000 0.5000 0.0000 0.0239
L_parietal lobe R 0.5699 0.0332 0.4662 0.6309
p 0.0000 0.7715 0.0001 0.0038
R_parietal lobe R 0.6029 0.1266 0.4573 0.7577
p 0.0000 0.2662 0.0001 0.0002
L_frontal lobe R 0.5808 0.0815 0.5514 0.7901
p 0.0000 0.4751 0.0000 0.0001
R_frontal lobe R 0.6043 0.1555 0.5214 0.7979
p 0.0000 0.1713 0.0000 0.0000
L_Pre R 0.5492 − 0.0356 0.4839 0.4321
p 0.0000 0.7558 0.0000 0.0647
R_Pre R 0.5359 − 0.0051 0.4701 0.4264
p 0.0000 0.9645 0.0001 0.0687
L_ACC R 0.5396 − 0.0318 0.5702 0.2565
p 0.0000 0.7812 0.0000 0.2891
R_ACC R 0.5074 0.0570 0.5480 0.3642
p 0.0000 0.6181 0.0000 0.1253
L_PCC R 0.4744 0.0901 0.4891 0.3325
p 0.0000 0.4299 0.0000 0.1643
R_PCC R 0.2522 0.0292 0.0430 0.2076
p 0.0009 0.7983 0.7317 0.3938
L_Ent R 0.4441 − 0.0206 0.3807 0.3183
p 0.0000 0.8571 0.0016 0.1841
R_Ent R 0.4927 0.0240 0.4267 0.5008
p 0.0000 0.8334 0.0004 0.0290
L_HP R 0.0344 0.0007 − 0.2287 0.2958
p 0.6563 0.9953 0.0647 0.2188
R_HP R 0.0599 − 0.0455 − 0.1864 0.2974
p 0.4377 0.6904 0.1339 0.2162
  1. The partial correlation analyses between nEV Aβ42 and regional AV45 SUVR were performed in all participants (n = 179), Aβ− NCs (n = 84), Aβ+ NCs (n = 72), and aMCI plus ADD individuals (n = 23), with correction for age, sex, and APOE ε4 status; the correlation coefficients and p values are listed
  2. Abbreviations: β-amyloid, NCs cognitively normal controls, aMCI amnestic mild cognitive impairment, ADD Alzheimer’s disease dementia, APOE apolipoprotein E, nEV neuronal-derived extracellular vesicle, AV45 [18F]florbetapir, SUVR standardized uptake value ratio, Pre precuneus, ACC anterior cingulate cortex, PCC posterior cingulate cortex, Ent entorhinal cortex, HP hippocampus