Skip to main content

Table 1 Dementia risk and protective factors assessed in this study

From: Dynamic functional connectivity patterns associated with dementia risk

Risk or protective factor Measure Relation with dementia risk
Clinical factors
 Diabetes Fasting blood sugar (g/L) Higher value = higher risk
 Obesity BMI (kg/m2) Higher value = lower risk
 Hypertension Mean of 3 consecutive measures of systolic blood pressure (mmHg) Higher value = higher risk
 Hypercholesterolemia LDL cholesterol (mmol/l) Higher value = higher risk
 Depressive symptoms Geriatric Depression Scale total score [14] Higher value = higher risk
Lifestyle factors
 Engagement in stimulating activities across the lifespan (educational, occupational, leisure, social, and physical activities) Lifetime of Experiences Questionnaire sub-scores in early-life, mid-life, and late-life [15] Higher value = lower risk
 Cognitive activity across the lifespan Cognitive Activity Questionnaire sub-scores in early-life, mid-life, and late-life [16] Higher value = lower risk
 Physical activity in the past 7 days Physical Activity Scale for the Elderly total score [17] Higher value = lower risk
 Smoking Number of pack year Higher value = higher risk
 Excessive alcohol consumption Averaged number of unit per week Higher value = higher risk
Genetic factors
 APOE4 genotype Number of APOE4 alleles ≥ 1 APOE4 allele = higher risk
  1. BMI body mass index, LDL low-density lipoprotein, APOE4 apolipoprotein e4