Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis

Table 1 Demographic and neuropsychiatric assessment data

	Asymptomatic MAPT carriers (n = 6)	Non-carriers in family (n = 12)	BvFTD patients (n = 32)	Controls (n =33)	p value^†, MAPT carriers vs non-carriers	p value*, bvFTD patients vs controls
Age	49.00 ± 3.90	42.25 ± 9.206	59.13 ± 9.97	54.27 ± 11.17	0.19	0.07
Sex (male/female)	3/3	7/5	16/16	15/18	0.99	0.81
Years of education	8.67 ± 0.52	10.55 ± 3.80	10.79 ± 4.64	11.23 ± 3.35	0.25	0.69
MMSE	28.67 ± 0.82	28.36 ± 2.06	12.54 ± 7.01	28.47 ± 2.17	0.92	< 0.0001
MoCA	26.50 ± 1.23	26.18 ± 3.06	9.323 ± 6.25	26.13 ± 3.40	0.68	< 0.0001
AVLT: immediate recall	23.83 ± 2.32	26.00 ± 7.32	8.15 ± 7.04	22.40 ± 5.25	0.94	< 0.0001
AVLT: delayed recall	8.67 ± 2.25	9.27 ± 3.16	1.74 ± 2.68	8.43 ± 3.48	0.71	< 0.0001
BNT	25.00 ± 1.00	24.90 ± 2.08	10.78 ± 6.52	25.38 ± 3.48	0.97	< 0.0001
CDR	0 ± 0	0 ± 0	1.76 ± 1.22	0 ± 0	–	< 0.0001
NPI-Q	0 (0–6)	0 (0–1)	24.13 ± 21.03	1.29 ± 4.53	0.89	0.0003
FBI	0 (0–6)	0 (0–2)	23.78 ± 14.39	1.667 ± 4.082	0.84	0.001
MBI-C	0 (0–14.25)	0 (0–1)	19.82 ± 15.25	2.20 ± 6.96	0.68	0.002

Data are presented as means ± standard deviation or medians (Q1–Q3)
AVLT, auditory verbal learning test; BNT, Boston Naming Test; CDR, Clinical Dementia Rating; FBI, Frontal Behavioral Inventory; MBI-C, Mild Behavioral Impairment Checklist; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; NPI-Q, Neuropsychiatry Inventory Questionnaire
^†Two-sided p-values for continuous variables refer to the Mann-Whitney tests, and two-sided p-values for categorical variables refer to Pearson’s chi-squared test
*Two-sided p-values for continuous variables refer to unpaired t-tests, and two-sided p-values for categorical variables refer to Pearson’s chi-squared test

ISSN: 1758-9193