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Table 3 Health and economic outcomes and neuropsychiatric symptom measures for early AD

From: Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer’s disease

Domain Potential Measure
Health and economic outcomes Resource Utilization in Dementia (RUD) Questionnaire
 • Structured interview with study partner to obtain information about patient and caregiver, including [55]
  o Healthcare resource utilization
  o Work status
  o Living accommodations
  o Level of formal and informal care attributable to AD, including caregiving time spent assisting patient’s instrumental ADLs or basic ADLs
 • Emerging evidence leveraging the RUD indicates that early AD, including MCI, poses a financial burden to the patient, caregiver, and society [56]
Neuropsychiatric symptoms Neuropsychiatric Inventory [57]
 • 12-item informant-based interview about delusions, hallucinations, anxiety, depression, agitation/aggression, euphoria, disinhibition, irritability/lability, apathy, aberrant motor activity, night-time behavioral disturbances, and appetite/eating abnormalities
 • Widely accepted measure of neuropsychiatric symptoms in dementia
Mild Cognitive Behavioral Impairment Checklist (MBI-C) [58]
 • Specifically developed as an MBI case ascertainment instrument, which also allows for the monitoring of MBI symptoms over time
 • 34-item instrument for completion by patient, close informant, or clinician
 • Assesses 5 domains of (1) decreased motivation; (2) emotional dysregulation; (3) impulse dyscontrol; (4) social inappropriateness; and (5) abnormal perception or thought content