Table 3 Health and economic outcomes and neuropsychiatric symptom measures for early AD
Domain | Potential Measure |
|---|---|
Health and economic outcomes | Resource Utilization in Dementia (RUD) Questionnaire • Structured interview with study partner to obtain information about patient and caregiver, including [55] o Healthcare resource utilization o Work status o Living accommodations o Level of formal and informal care attributable to AD, including caregiving time spent assisting patient’s instrumental ADLs or basic ADLs • Emerging evidence leveraging the RUD indicates that early AD, including MCI, poses a financial burden to the patient, caregiver, and society [56] |
Neuropsychiatric symptoms | Neuropsychiatric Inventory [57] • 12-item informant-based interview about delusions, hallucinations, anxiety, depression, agitation/aggression, euphoria, disinhibition, irritability/lability, apathy, aberrant motor activity, night-time behavioral disturbances, and appetite/eating abnormalities • Widely accepted measure of neuropsychiatric symptoms in dementia Mild Cognitive Behavioral Impairment Checklist (MBI-C) [58] • Specifically developed as an MBI case ascertainment instrument, which also allows for the monitoring of MBI symptoms over time • 34-item instrument for completion by patient, close informant, or clinician • Assesses 5 domains of (1) decreased motivation; (2) emotional dysregulation; (3) impulse dyscontrol; (4) social inappropriateness; and (5) abnormal perception or thought content |