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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Pilot study of repeated blood-brain barrier disruption in patients with mild Alzheimer’s disease with an implantable ultrasound device

Fig. 1

The SonoCloud-1 is a 1-MHz implantable ultrasound device that is implanted within the skull thickness (extradural) and activated at each treatment cycle by connecting it using a transdermal needle to an external radiofrequency generator. In this study, the SonoCloud-1 was implanted to target and temporarily disrupt the BBB above the left supramarginal gyrus

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