Fig. 5From: Correction to: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosisSLCP treatment partially preserved dendritic arborization and dendritic spine number in hippocampus of 5xFAD mice. After 2 months of treatment with SLCP (100 mg/kg), the brains of the 6- and 12-month-old 5xFAD and age-matched control mice were processed using Golgi-Cox stain for 2 weeks. Coronal sections (120 μm) were stained with 75% ammonium solution and 1% sodium thiosulphate. CA1 and CA3 neurons and dendritic spines from apical and basal branches (primary, secondary, and tertiary) were imaged using 40x and 100x objectives, respectively (Olympus). a, f Representative images of CA1 and CA3 pyramidal neurons showed a decreased number of apical and basal branches in vehicle-treated 5xFAD mice in comparison to WT and SLCP-treated mice. b, d Representative dendritic spine images from apical and basal branches. c, e Morphometric data revealed that the number of dendritic spines in CA1 neurons were significantly decreased in vehicle-treated 5xFAD mice in comparison to WT and SLCP-treated mice. g, i Representative dendritic spine images from CA3 apical and basal branches, respectively. h, j Morphometric analyses showed that the number of dendritic spines were significantly decreased in vehicle-treated 5xFAD mice in comparison to their WT counterparts, and to SLCP-treated 5xFAD mice. Scale bar = 100 μm and is applicable to all images. *p < 0.05, **p < 0.01 in comparison to WT + vehicle, 5xFAD + SLCP, and WT + SLCPBack to article page