Novel diagnostic tools for identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy: patient-level, single-group, diagnostic trial

Table 4 C-statistic for the prediction model in the diagnosis of AD or MCI^b

	AUC	Sensitivity (%)	Specificity (%)
Prediction model as AD
Olfactory-stimulated oxygenation difference in the orbitofrontal cortex	0.819 (0.736 to 0.902)	93.8	67.9
Standard uptake value ratio (amyloid PET)	0.786 (0.656 to 0.917)	93.3	57.1
Hippocampal volume (MRI)	0.810 (0.673 to 0.947)	86.7	81.3
Prediction model as AD and MCI
Olfactory-stimulated oxygenation difference in the orbitofrontal cortex	0.873 (0.800 to 0.945)	88.1	81.8
Standard uptake value ratio (amyloid PET)	0.745 (0.640 to 0.850)	80.0	59.6
Hippocampal volume	0.733 (0.621 to 0.846)	61.0	92.6
Prediction model as MCI (excluded patients with AD)^a
Olfactory-stimulated oxygenation difference in the orbitofrontal cortex	0.852 (0.764 to 0.939)	84.6	81.8
Standard uptake value ratio (amyloid PET)	0.690 (0.557 to 0.823)	52.0	80.8
Hippocampal volume (MRI)	0.659 (0.515 to 0.804)	50.0	88.9

Abbreviations: AD Alzheimer’s disease, AUC area under the curve, CN cognitively normal, MCI mild cognitive impairment
^aWe excluded 16 patients with AD; therefore, the sample number for this analysis is 81
^bThe diagnostic criteria for MCI were based on the Jak/Bondi comprehensive criteria

ISSN: 1758-9193