Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease

Table 1 Number of ROSMAP participants with RNA-seq data by APOE genotype and batch

APOE genotype	Blood batch 1		Blood batch 2		Combined blood		Brain	Blood-brain overlap
APOE genotype	AD	CTRL	AD	CTRL	AD	CTRL	AD	CTRL	AD	CTRL
ɛ2/ɛ2**	0	0	0	1	0	1	0	5	0	1
ɛ2/ɛ3	5	3	9	9	14	12	32	39	12	8
ɛ3/ɛ3	16	11	44	31	60	42	197	158	49	33
ɛ2/ɛ4**	1	1	5	0	6	1	9	4	4	1
ɛ3/ɛ4*	8	1	21	10	21	10	101	25	22	8
ɛ4/ɛ4**	1	0	1	0	0	0	5	1	2	0
NA	0	0	1	0	1	0	0	0	0	0
Total	31	16	81	51	112	67	344	232	89	51

Blood batch 3 was excluded because it contained controls only
*APOE ɛ3/ɛ4 subjects from blood batch 1 were excluded from all analyses due to the small sample size
**ɛ2/ɛ2, ɛ2/ɛ4, and ɛ4/ɛ4 subjects were not analyzed separately due to the small sample size
NA, APOE genotype not available

ISSN: 1758-9193