Fig. 2
Significant pathways in the blood and brain by the APOE genotype. a Significant pathways (adjusted P < 0.05) within APOE genotype groups that are enriched for differentially expressed genes in the blood and brain combined are plotted according to the normalized enrichment score. Enrichment score indicates whether the genes in the pathway are upregulated (positive) or downregulated (negative) in AD. b Heatmap shows strength and direction of association of levels of proteins involved in vascular damage with the expression of leading-edge genes from significant pathways where enrichment scores are in opposite directions between APOE ε4 carriers (+) and non-carriers (-). Genes whose expression was significantly (P < 4.67 × 10−4) associated with the level of at least one protein (indicated by an asterisk) are shown