| |
Odds of conversion from CDR = 0 to CDR > 0
|
|---|
|
Univariable
|
Multivariable
|
|---|
|
p-value
|
OR (95% CI)
|
p-value
§
|
OR
b
(95% CI)
|
|---|
|
Age (years)
|
0.996
|
1 (0.951–1.051)
|
-
|
-
|
|
Sex (male versus female)
|
0.911
|
0.963 (0.496–1.87)
|
-
|
-
|
|
Ln ICA calcium score
|
0.210
|
0.891 (0.743–1.068)
|
-
|
-
|
|
Ln ICA calcium volume
|
0.265
|
0.899 (0.845–1.084)
|
-
|
-
|
|
WMH voluma (1000 mm3)
|
0.340
|
1.01 (0.989–1.032)
|
-
|
-
|
|
Total hippocampal volumea (100 mm3)
|
0.006
|
0.940 (0.9–0.982)
|
0.071
|
0.958 (0.915–1.004)
|
|
AD cortical signature thickness (mm)
|
0.125
|
0.110 (0.007–1.837)
|
-
|
-
|
|
Centiloida (5 unit)
|
0.003
|
1.08 (1.027–1.136)
|
0.012
|
1.070 (1.015–1.127)
|
-
Abbreviations: ICA, internal carotid artery, WMH volume, white matter hyperintensities volume, Centiloid, measure of global amyloid disposition based on conversion of PIB or AV45 PET SUVRs to a standardized scale, AD cortical signature thickness, cortical thickness in signature regions affected in Alzheimer disease (see Dincer et al. 2020), Ln ICA calcium score/volume, natural log transformation of internal carotid artery Agatston calcium score/volume, OR (95% CI), odds ratio and 95% confidence interval
-
aOdds ratios are demonstrated for 1000-mm3 increments in WMH volume, 100-mm3 increments in total hippocampal volume, and 5-unit increments in Centiloid scale
-
bSignificant variables from the univariable model were entered into a stepwise multivariable model where a probability of 0.3 was set to enter the variables into the model and a probability of 0.1 to remove variables from the model
-
§
p-values were corrected for multiple comparisons through estimation of the false discovery rate via the Benjamini and Hochberg method. Variables with a p-value of 0.05 were considered statistically significant in both regression models (denoted in bold)
