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Table 1 Baseline cohort characteristics

From: Sensitive and reproducible MEG resting-state metrics of functional connectivity in Alzheimer’s disease

Baseline characteristics Test cohort (n = 57) Validation cohort (n = 56)
SCD (n = 29) AD (n = 28) SCD (n = 27) AD (n = 29)
Age (years) 56.7 ± 8.4 66.3 ± 7.4* 56.3 ± 10.6 64.0 ± 6.8*
Sex (female, (%)) 11 (38) 16 (57) 11 (41) 16 (55)
Symptom duration (years)a 3.5 ± 2.6 3.3 ± 2.3 3.3 ± 2.4 2.7 ± 1.6
Education level (median, (IQR))b 6 (3–7) 5 (3–7) 5 (3–7) 5 (3–7)
MMSE score (median, (IQR)) 28 (26–30) 20 (12–28)*† 27 (24–30) 22 (15–29)*†
Cerebrospinal fluid n = 19 n = 23 n = 18 n = 26
 Aβ 1–42 (mean ± SD) 1250 ± 159 544 ± 122* 1158 ± 224 568 ± 112*
 t-tau (mean ± SD) 302.1 ± 92.0 831.4 ± 465.0* 295.6 ± 176.4 661.9 ± 337.2*
 p-tau (mean ± SD) 48.9 ± 11.7 96.6 ± 37.3* 46.2 ± 12.3 81.2 ± 28.2*
Amyloid-PET n = 16 n = 14 n = 5 n = 7
 Positive PET (%) 0% 100% 0% 100%
 Epoch quality (median, IQR) 2 (1–3) 2 (1–3) 2 (1–3) 2 (1–3)
  1. n.a. not available
  2. aTime between the start of symptoms and diagnosis
  3. bEducation level according to Verhage score (range 1–7). Depicted are the mean values ± SD or median with the interquartile range (IQR) where appropriate
  4. *Significant (p < 0.05) group differences between AD and SCD
  5. †Significant (p < 0.05) group differences between the test and validation cohorts
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Alzheimer's Research & Therapy

ISSN: 1758-9193