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Table 1 Baseline cohort characteristics

From: Sensitive and reproducible MEG resting-state metrics of functional connectivity in Alzheimer’s disease

Baseline characteristics

Test cohort (n = 57)

Validation cohort (n = 56)

SCD (n = 29)

AD (n = 28)

SCD (n = 27)

AD (n = 29)

Age (years)

56.7 ± 8.4

66.3 ± 7.4*

56.3 ± 10.6

64.0 ± 6.8*

Sex (female, (%))

11 (38)

16 (57)

11 (41)

16 (55)

Symptom duration (years)a

3.5 ± 2.6

3.3 ± 2.3

3.3 ± 2.4

2.7 ± 1.6

Education level (median, (IQR))b

6 (3–7)

5 (3–7)

5 (3–7)

5 (3–7)

MMSE score (median, (IQR))

28 (26–30)

20 (12–28)*†

27 (24–30)

22 (15–29)*†

Cerebrospinal fluid

n = 19

n = 23

n = 18

n = 26

 Aβ 1–42 (mean ± SD)

1250 ± 159

544 ± 122*

1158 ± 224

568 ± 112*

 t-tau (mean ± SD)

302.1 ± 92.0

831.4 ± 465.0*

295.6 ± 176.4

661.9 ± 337.2*

 p-tau (mean ± SD)

48.9 ± 11.7

96.6 ± 37.3*

46.2 ± 12.3

81.2 ± 28.2*

Amyloid-PET

n = 16

n = 14

n = 5

n = 7

 Positive PET (%)

0%

100%

0%

100%

 Epoch quality (median, IQR)

2 (1–3)

2 (1–3)

2 (1–3)

2 (1–3)

  1. n.a. not available
  2. aTime between the start of symptoms and diagnosis
  3. bEducation level according to Verhage score (range 1–7). Depicted are the mean values ± SD or median with the interquartile range (IQR) where appropriate
  4. *Significant (p < 0.05) group differences between AD and SCD
  5. †Significant (p < 0.05) group differences between the test and validation cohorts
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Alzheimer's Research & Therapy

ISSN: 1758-9193