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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Fig. 3

GCSi treatment reduces soluble Aβ42 accumulation in the brains of AD mice. Soluble Aβ40 and Aβ42 species in the amygdala, hippocampus, and cortex of AD (Tg2576) mice after GCSi treatment from A 12 to 68 weeks of age and B 70 to 90 weeks of age. Columns not connected by the same letter are significantly (p = 0.01) different from each other. Error bars represent ± SEM

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Alzheimer's Research & Therapy

ISSN: 1758-9193