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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

Fig. 3

Model of the interaction of D-peptides with the PHF6 fibril residues. PHF6 fibrillar oligomer VQIVYK (PDB:2ON9 [10];) complexed with the following D-peptides: A TLKIVW [9], B TTSLQMRLYYPP (TD28) [50], and C SVFKLSLTDAAS (ISAD1). All molecules are depicted as sticks. PHF6 residues are colored according to their type (polar: green; basic: blue; hydrophobic: white). Atoms in peptide ligands are colored according to their chemical elements. Blue ellipses mark the interactions between the anchoring basic residue in the ligand and Q307 in PHF6. Red, orange, and dotted black circles indicate the Φ-positions of the D-peptide. Structurally equivalent positions of different peptides are encircled by the same color. The black circle marks a position present only in those peptides that exhibit the extended hydrophobic motif. Key residues in PHF6 and the D-peptides are labeled. Residue numbers with a prime indicate the second PHF6 layer, and black italic numbers refer to the D-peptide

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Alzheimer's Research & Therapy

ISSN: 1758-9193