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Table 4 Mean (SD) 2FA binding (VT/fp) within the AD and MCI groups, for those on and off AChEI medication

From: Cholinergic receptor binding in unimpaired older adults, mild cognitive impairment, and Alzheimer’s disease dementia

Variable MCI AD
Off aAChEI (n = 20) Ona AChEI (n = 8) Off AChEI (n = 9) On AChEI (n = 23)
L thalamus 12.25 (1.76) 11.91 (2.50) 12.96 (1.57)b 10.94 (1.98)
R thalamus 12.42 (1.64) 12.28 (2.62) 13.12 (1.53)b 11.17 (2.34)
L hippocampus 7.15 (.83) 7.63 (1.20) 7.50 (.84)b 5.88 (1.19)
R hippocampus 7.18 (.80) 7.44 (1.30) 7.34 (.82)b 6.14 (.93)
L caudate 5.92 (1.62) 5.16 (2.28) 5.40 (1.85) 4.46 (1.91)
R caudate 6.15 (1.52) 5.50 (1.39) 5.90 (1.64) 4.31 (2.11)
L entorhinal 8.55 (1.22) 8.51 (1.28) 8.51 (.87) 8.48 (1.77)
R entorhinal 10.21 (1.35) 10.51 (2.01) 10.13 (1.11) 9.67 (2.48)
L insula 8.22 (.95) 8.93 (1.01) 8.67 (1.16) 7.87 (1.39)
R insula 8.44 (.80) 8.95 (1.07) 8.72 (1.38) 8.00 (1.05)
L anterior cingulate 10.17 (1.20) 10.63 (1.76) 10.71 (1.43) 10.15 (1.93)
R anterior cingulate 10.22 (1.15) 10.47 (1.55) 10.70 (1.43) 9.68 (2.22)
  1. aOff and on refers to the current use of cholinesterase inhibitor medication
  2. bSignificant difference within the diagnostic group, p < .05