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Table 3 Pairwise comparisons of 2FA binding (VT/fp) between the diagnostic groups, voxel-wise analysis

From: Cholinergic receptor binding in unimpaired older adults, mild cognitive impairment, and Alzheimer’s disease dementia

Regions K PFWE-corr T statistic Coordinates
CU > AD
 Bilateral hippocampus, temporal pole, insula, caudate, putamen, thalamus 9285 0 8.03 [30, − 10, − 12]
 Bilateral anterior cingulate 238 0 6.2 [2, 34, 26]
 Right temporal pole 44 0.003 5.64 [28, 18, − 44]
 Left calcarine fissure 34 0.005 5.49 [− 14, − 62, 8]
MCI > AD
 Right hippocampus 143 0 6.09 [40, − 34, − 6]
 Left hippocampus 69 0.001 5.84 [− 36, − 34, − 6]
CU > MCI (within the medial temporal lobe only)
 Right entorhinal cortex 7 0.048 3.76 [30, − 10, − 32]
 Left entorhinal cortex 69 0.013 4.17 [− 28, − 12, − 34]
  1. K = number of voxels. Coordinates referenced to MNI space
  2. Findings for CU > AD and MCI > AD are significant across the entire brain at the voxel level p < .05 FWE-corrected. Findings for CU > MCI are significant at p < .05 using small volume correction of MTL