Cholinergic receptor binding in unimpaired older adults, mild cognitive impairment, and Alzheimer’s disease dementia

Table 3 Pairwise comparisons of 2FA binding (V_T/f_p) between the diagnostic groups, voxel-wise analysis

Regions	K	P_FWE-corr	T statistic	Coordinates
CU > AD
Bilateral hippocampus, temporal pole, insula, caudate, putamen, thalamus	9285	0	8.03	[30, − 10, − 12]
Bilateral anterior cingulate	238	0	6.2	[2, 34, 26]
Right temporal pole	44	0.003	5.64	[28, 18, − 44]
Left calcarine fissure	34	0.005	5.49	[− 14, − 62, 8]
MCI > AD
Right hippocampus	143	0	6.09	[40, − 34, − 6]
Left hippocampus	69	0.001	5.84	[− 36, − 34, − 6]
CU > MCI (within the medial temporal lobe only)
Right entorhinal cortex	7	0.048	3.76	[30, − 10, − 32]
Left entorhinal cortex	69	0.013	4.17	[− 28, − 12, − 34]

K = number of voxels. Coordinates referenced to MNI space
Findings for CU > AD and MCI > AD are significant across the entire brain at the voxel level p < .05 FWE-corrected. Findings for CU > MCI are significant at p < .05 using small volume correction of MTL

ISSN: 1758-9193