Table 1 Baseline demographic and clinical characteristics of 6851 participants according to all-cause dementia over a 12-year follow-up

Sex, women

4118

60.11

3672

59.65

446

64.17

1.03 [0.89–1.21]

0.67

Education (years)

< 0.0001

 < 6

1583

23.11

1356

22.03

227

32.66

1

 [6; 11]

2484

36.26

2276

36.97

208

29.93

0.57 [0.47–0.69]

 ≥ 12

2784

40.64

2524

41.00

260

37.41

0.61 [0.51–0.73]

Live alone, yes

2338

34.13

2062

33.50

276

39.71

1.00 [0.85–1.16]

0.97

BMI (kg/m²)

0.17

 <25

3280

47.88

2959

48.07

321

46.19

1

 [25; 30]

2683

39.19

2399

38.97

284

40.86

1.13 [0.96–1.32]

 ≥ 30

888

12.96

798

12.96

90

12.95

1.21 [0.96–1.53]

Smoking status, current/past

2692

39.29

2442

39.67

250

35.97

0.99 [0.85–1.16]

0.92

Mobility, confined

352

5.14

279

4.53

73

10.50

1.98 [1.54–2.53]

< 0.0001

Alcohol (g/day)

0.45

 < 12

4423

64.56

3959

64.31

464

66.76

1

 [12; 36[

1835

26.78

1663

27.01

172

24.75

0.91 [0.77–1.09]

 ≥ 36

593

8.66

534

8.67

59

8.49

1.08 [0.83–1.42]

Caffeine (mg/day)

0.79

 ≤ 125

1767

25.79

1577

25.62

190

27.34

1

 ]125; 375]

4029

58.81

3629

58.95

400

57.55

0.95 [0.80–1.13]

 > 375

1055

15.40

950

15.43

105

15.11

1.00 [0.79–1.27]

Hypercholesterolemia, yes

3888

56.75

3483

56.58

405

58.27

1.11 [0.95–1.29]

0.19

Diabetes mellitus, yes

613

8.95

516

8.38

97

13.96

1.89 [1.52–2.34]

< 0.0001

Hypertension, yes

4080

59.55

3640

59.13

440

63.31

1.06 [0.91–1.24]

0.46

History of cardiovascular disorders, yes

1882

27.47

1660

26.97

222

31.94

1.17 [1.00–1.38]

0.05

Depressive status^a, yes

1726

25.19

1482

24.07

244

35.11

1.67 [1.43–1.95]

< 0.0001

Carrier of the APOE-ε4 allele, yes

1346

19.65

1151

18.70

195

28.06

1.98 [1.68–2.34]

< 0.0001

In a subsample of 984 subjects

 Aβ₄₀ (pg/ml)

0.91

  < 214.31

328

33.33

295

33.26

33

34.02

1

  [214.31; 251.96]

328

33.33

297

33.48

31

31.96

0.92 [0.56; 1.50]

  > 251.96

328

33.33

295

33.26

33

34.02

0.91 [0.56; 1.47]

 Aβ₄₂ (pg/ml)

0.09

  < 33.69

326

33.23

292

33.03

34

35.05

1

  [33.69; 42.30]

329

33.54

289

32.69

40

41.24

1.15 [0.73; 1.81]

  > 42.30

326

33.23

303

34.28

23

23.71

0.65 [0.38; 1.10]

Ratio Aβ₄₂/Aβ₄₀

0.24

  < 0.150

330

33.64

293

33.14

37

38.14

1

  [0.150; 0.182]

319

32.52

284

32.13

35

36.08

1.01 [0.63; 1.60]

  > 0.182

332

33.84

307

34.73

25

25.77

0.68 [0.41; 1.12]