Variables | Whole sample, n = 6851 | Free of dementia, n = 6156 | Incident dementia, n = 695 | HR [95%CI] | p value | |||
---|---|---|---|---|---|---|---|---|
n | % | n | % | n | % | |||
Sex, women | 4118 | 60.11 | 3672 | 59.65 | 446 | 64.17 | 1.03 [0.89–1.21] | 0.67 |
Education (years) | < 0.0001 | |||||||
< 6 | 1583 | 23.11 | 1356 | 22.03 | 227 | 32.66 | 1 | |
[6; 11] | 2484 | 36.26 | 2276 | 36.97 | 208 | 29.93 | 0.57 [0.47–0.69] | |
≥ 12 | 2784 | 40.64 | 2524 | 41.00 | 260 | 37.41 | 0.61 [0.51–0.73] | |
Live alone, yes | 2338 | 34.13 | 2062 | 33.50 | 276 | 39.71 | 1.00 [0.85–1.16] | 0.97 |
BMI (kg/m2) | 0.17 | |||||||
<25 | 3280 | 47.88 | 2959 | 48.07 | 321 | 46.19 | 1 | |
[25; 30] | 2683 | 39.19 | 2399 | 38.97 | 284 | 40.86 | 1.13 [0.96–1.32] | |
≥ 30 | 888 | 12.96 | 798 | 12.96 | 90 | 12.95 | 1.21 [0.96–1.53] | |
Smoking status, current/past | 2692 | 39.29 | 2442 | 39.67 | 250 | 35.97 | 0.99 [0.85–1.16] | 0.92 |
Mobility, confined | 352 | 5.14 | 279 | 4.53 | 73 | 10.50 | 1.98 [1.54–2.53] | < 0.0001 |
Alcohol (g/day) | 0.45 | |||||||
< 12 | 4423 | 64.56 | 3959 | 64.31 | 464 | 66.76 | 1 | |
[12; 36[ | 1835 | 26.78 | 1663 | 27.01 | 172 | 24.75 | 0.91 [0.77–1.09] | |
≥ 36 | 593 | 8.66 | 534 | 8.67 | 59 | 8.49 | 1.08 [0.83–1.42] | |
Caffeine (mg/day) | 0.79 | |||||||
≤ 125 | 1767 | 25.79 | 1577 | 25.62 | 190 | 27.34 | 1 | |
]125; 375] | 4029 | 58.81 | 3629 | 58.95 | 400 | 57.55 | 0.95 [0.80–1.13] | |
> 375 | 1055 | 15.40 | 950 | 15.43 | 105 | 15.11 | 1.00 [0.79–1.27] | |
Hypercholesterolemia, yes | 3888 | 56.75 | 3483 | 56.58 | 405 | 58.27 | 1.11 [0.95–1.29] | 0.19 |
Diabetes mellitus, yes | 613 | 8.95 | 516 | 8.38 | 97 | 13.96 | 1.89 [1.52–2.34] | < 0.0001 |
Hypertension, yes | 4080 | 59.55 | 3640 | 59.13 | 440 | 63.31 | 1.06 [0.91–1.24] | 0.46 |
History of cardiovascular disorders, yes | 1882 | 27.47 | 1660 | 26.97 | 222 | 31.94 | 1.17 [1.00–1.38] | 0.05 |
Depressive statusa, yes | 1726 | 25.19 | 1482 | 24.07 | 244 | 35.11 | 1.67 [1.43–1.95] | < 0.0001 |
Carrier of the APOE-ε4 allele, yes | 1346 | 19.65 | 1151 | 18.70 | 195 | 28.06 | 1.98 [1.68–2.34] | < 0.0001 |
In a subsample of 984 subjects | ||||||||
Aβ40 (pg/ml) | 0.91 | |||||||
< 214.31 | 328 | 33.33 | 295 | 33.26 | 33 | 34.02 | 1 | |
[214.31; 251.96] | 328 | 33.33 | 297 | 33.48 | 31 | 31.96 | 0.92 [0.56; 1.50] | |
> 251.96 | 328 | 33.33 | 295 | 33.26 | 33 | 34.02 | 0.91 [0.56; 1.47] | |
Aβ42 (pg/ml) | 0.09 | |||||||
< 33.69 | 326 | 33.23 | 292 | 33.03 | 34 | 35.05 | 1 | |
[33.69; 42.30] | 329 | 33.54 | 289 | 32.69 | 40 | 41.24 | 1.15 [0.73; 1.81] | |
> 42.30 | 326 | 33.23 | 303 | 34.28 | 23 | 23.71 | 0.65 [0.38; 1.10] | |
Ratio Aβ42/Aβ40 | 0.24 | |||||||
< 0.150 | 330 | 33.64 | 293 | 33.14 | 37 | 38.14 | 1 | |
[0.150; 0.182] | 319 | 32.52 | 284 | 32.13 | 35 | 36.08 | 1.01 [0.63; 1.60] | |
> 0.182 | 332 | 33.84 | 307 | 34.73 | 25 | 25.77 | 0.68 [0.41; 1.12] |