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Neurotransmitter transport
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MEF2Ca
|
Myocyte-specific enhancer factor 2C
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MEF2C mRNA expression levels were correlated with AD pathology
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RIMS1
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Regulating synaptic membrane exocytosis protein 1
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An altered protein expression in RIMS1 during AD pathology
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Beta-amyloid-related biologic process
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APOEa
|
Apolipoprotein E
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Affect Aβ production, aggregation, and clearance
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CHRNA7
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Neuronal acetylcholine receptor subunit alpha-7
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Bind to Aβ with very high affinity, providing therapeutic insight into AD
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SORL1a
|
Sortilin-related receptor
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Reduce Aβ generation by trafficking APP away from amyloidogenic cleavage sites
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ADAM10a
|
Disintegrin and metalloproteinase domain-containing protein 10
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Constitutive α-secretase in the process of amyloid-β protein precursor (AβPP) cleavage
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LRP2
|
Low-density lipoprotein receptor-related protein 2
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rs3755166 polymorphism within LRP2 gene is associated with susceptibility to AD in the Chinese population
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Long-term synaptic potentiation
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MAPK1
|
Mitogen-activated protein kinase 1
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Beta-amyloid activates the MAPK cascade via hippocampal CHRNA7
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PTK2Ba
|
Protein-tyrosine kinase 2-beta
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An in vivo modulator and early marker of Tau pathology
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Oxidative stress
| |
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FOXO3
|
Forkhead box protein O3
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Activate BCL2L11 and FASLG to promote neuronal death and aberrant Aβ processing
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NOS1
|
Nitric oxide synthase
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Loss of endothelial NOS promotes p25 production and Tau phosphorylation
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NFKB1
|
Nuclear factor NF-kappa-B p105 subunit
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Involve in neuroinflammation, synaptic plasticity, learning, and memory implicated in AD
|
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ESR1
|
Estrogen receptor
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Interact with tau protein in vivo, and prevent glutamate excitotoxic injury by Aβ through estrogen signaling mechanisms
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