The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex

Table 1 Demographic and pathological characteristics of participants by diagnostic group

	bvAD	tAD	bvFTD	Controls	p-value^†
N	9	6	18	13
Age at death	70.1 (9.0)	79.7 (12.7)	64.8 (8.8)	66.8 (11.4)	0.68
Sex, no. of females, %	5, 55.6	2, 33.3	10, 55.6	6, 50.0	0.78
Thal stage, mean	5.0 (0.0)	4.8 (0.4)	0.61 (0.89)	1.67 (1.43)	bvAD>CN, p < 0.001, tAD>CN, p < 0.001, bvAD>bvFTD, p < 0.001, tAD>bvFTD, p < 0.001
Braak stage, mean	5.6 (0.5)	5.6 (0.5)	1.11 (1.20)	0.67 (0.75)	bvAD>CN, p < 0.001, tAD>CN, p < 0.001, tAD>bvFTD, p < 0.001
LBD◊ present in amygdala or brainstem, %	44.4	50	n/a	n/a
LATE□ present, %	11.1	50	n/a	n/a

^†Significant differences in age were assessed by an ANOVA test and differences in sex were assessed with a χ² test, differences in Thal and Braak stages were assessed with emmeans post hoc tests in R version 4.0.2 [35]
◊LBD = Lewy body disease, assessed as present or absent
□LATE = Limbic predominant age related TDP-43 pathology, assessed as present or absent
bvAD behavioral variant of Alzheimer’s disease, tAD typical AD, bvFTD behavioral variant frontotemporal dementia

ISSN: 1758-9193