|
Characteristic
|
Data available
|
CU
|
Data available
|
MCI
|
p value
|
|---|
|
Median (IQR) / N (%)
|
Median (IQR) / N (%)
|
|---|
|
Age (years)
|
864
|
75.6 (67.0, 80.9)
|
131
|
81.4 (75.6, 85.3)
|
<0.0001a
|
|
Male
|
864
|
479 (55.4%)
|
131
|
79 (60.3%)
|
0.2957b
|
|
Education (years)
|
864
|
15.0 (12.0, 16.0)
|
131
|
13.0 (12.0, 15.0)
|
<0.0001a
|
|
≥ 1 APOE ε4
|
864
|
228 (26.4%)
|
131
|
45 (34.4%)
|
0.0570b
|
|
Plasma total tau (pg/mL)
|
864
|
2.53 (1.82, 3.30)
|
131
|
2.83 (1.94, 3.60)
|
0.0391a
|
|
Plasma NfL (pg/mL)
|
864
|
17.0 (11.8, 23.9)
|
131
|
23.1 (16.7, 32.5)
|
<0.0001a
|
|
Body mass index (kg/m2)
|
860
|
27.5 (24.9, 31.0)
|
130
|
26.9 (23.6, 29.7)
|
0.0211a
|
|
Hypertension
|
864
|
571 (66.1%)
|
131
|
100 (76.3%)
|
0.0197b
|
|
Stroke
|
864
|
21 (2.4%)
|
131
|
10 (7.6%)
|
0.0014b
|
|
Myocardial infarction
|
864
|
96 (11.1%)
|
131
|
29 (22.1%)
|
0.0004b
|
|
Follow-up time (years)
|
864
|
6.2 (4.9, 7.5)
|
131
|
5.0 (2.7, 6.3)
|
<0.0001a
|
|
Cognitive z-score
|
|
Global
|
826
|
0.242 (−0.338, 0.830)
|
122
|
−1.325 (−1.953, −0.984)
|
<0.0001a
|
|
Memory
|
859
|
0.259 (−0.386, 0.835)
|
128
|
−1.470 (−1.902, −0.809)
|
<0.0001a
|
|
Language
|
844
|
0.243 (−0.400, 0.777)
|
126
|
−1.067 (−1.646, −0.390)
|
<0.0001a
|
|
Visuospatial ability
|
841
|
0.216 (−0.346, 0.761)
|
124
|
−1.140 (−2.068, −0.370)
|
<0.0001a
|
|
Attention
|
841
|
0.181 (−0.444, 0.761)
|
125
|
−0.765 (−1.565, −0.061)
|
<0.0001a
|
|
Cortical thickness
|
|
Frontal
|
583
|
2.325 (2.224, 2.411)
|
85
|
2.236 (2.160, 2.337)
|
<0.0001a
|
|
Parietal
|
582
|
2.629 (2.540, 2.729)
|
85
|
2.504 (2.406, 2.610)
|
<0.0001a
|
|
Temporal
|
583
|
2.076 (1.987, 2.169)
|
85
|
1.987 (1.924, 2.076)
|
<0.0001a
|
|
Occipital
|
583
|
1.879 (1.800, 1.958)
|
85
|
1.808 (1.753, 1.886)
|
<0.0001a
|
|
Amyloid PET ≥ 1.48 SUVR
|
441
|
129 (29.3%)
|
59
|
39 (66.1%)
|
<0.0001a
|
|
Hippocampal volume (cm3)
|
584
|
7.35 (6.84, 7.89)
|
85
|
6.85 (6.22, 7.21)
|
<0.0001a
|
|
WMH volume (mm3)
|
341
|
0.005 (0.003, 0.011)
|
53
|
0.014 (0.008, 0.021)
|
<0.0001a
|
|
Corpus callosum FA
|
369
|
0.643 (0.614, 0.662)
|
36
|
0.625 (0.565, 0.648)
|
0.0036a
|
|
Infarcts (total)
|
419
|
0 (0)
|
48
|
0 (0, 1)
|
<0.0001a
|
- Hippocampal volume measures were adjusted for total intracranial volume
- APOE apolipoprotein E, FA fractional anisotropy, IQR interquartile range, MCI mild cognitive impairment, NfL neurofilament light, WMH white matter hyperintensity
- aKruskal Wallis rank sum test
- bPearson’s Chi-Square test
