Table 1 Mayo Clinic Study of Aging participant baseline characteristics

Age (years)

864

75.6 (67.0, 80.9)

131

81.4 (75.6, 85.3)

<0.0001^a

Male

864

479 (55.4%)

131

79 (60.3%)

0.2957^b

Education (years)

864

15.0 (12.0, 16.0)

131

13.0 (12.0, 15.0)

<0.0001^a

≥ 1 APOE ε4

864

228 (26.4%)

131

45 (34.4%)

0.0570^b

Plasma total tau (pg/mL)

864

2.53 (1.82, 3.30)

131

2.83 (1.94, 3.60)

0.0391^a

Plasma NfL (pg/mL)

864

17.0 (11.8, 23.9)

131

23.1 (16.7, 32.5)

<0.0001^a

Body mass index (kg/m²)

860

27.5 (24.9, 31.0)

130

26.9 (23.6, 29.7)

0.0211^a

Hypertension

864

571 (66.1%)

131

100 (76.3%)

0.0197^b

Stroke

864

21 (2.4%)

131

10 (7.6%)

0.0014^b

Myocardial infarction

864

96 (11.1%)

131

29 (22.1%)

0.0004^b

Follow-up time (years)

864

6.2 (4.9, 7.5)

131

5.0 (2.7, 6.3)

<0.0001^a

 Global

826

0.242 (−0.338, 0.830)

122

−1.325 (−1.953, −0.984)

<0.0001^a

 Memory

859

0.259 (−0.386, 0.835)

128

−1.470 (−1.902, −0.809)

<0.0001^a

 Language

844

0.243 (−0.400, 0.777)

126

−1.067 (−1.646, −0.390)

<0.0001^a

 Visuospatial ability

841

0.216 (−0.346, 0.761)

124

−1.140 (−2.068, −0.370)

<0.0001^a

 Attention

841

0.181 (−0.444, 0.761)

125

−0.765 (−1.565, −0.061)

<0.0001^a

 Frontal

583

2.325 (2.224, 2.411)

85

2.236 (2.160, 2.337)

<0.0001^a

 Parietal

582

2.629 (2.540, 2.729)

85

2.504 (2.406, 2.610)

<0.0001^a

 Temporal

583

2.076 (1.987, 2.169)

85

1.987 (1.924, 2.076)

<0.0001^a

 Occipital

583

1.879 (1.800, 1.958)

85

1.808 (1.753, 1.886)

<0.0001^a

Amyloid PET ≥ 1.48 SUVR

441

129 (29.3%)

59

39 (66.1%)

<0.0001^a

Hippocampal volume (cm³)

584

7.35 (6.84, 7.89)

85

6.85 (6.22, 7.21)

<0.0001^a

WMH volume (mm³)

341

0.005 (0.003, 0.011)

53

0.014 (0.008, 0.021)

<0.0001^a

Corpus callosum FA

369

0.643 (0.614, 0.662)

36

0.625 (0.565, 0.648)

0.0036^a

Infarcts (total)

419

0 (0)

48

0 (0, 1)

<0.0001^a