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Table 1 Mayo Clinic Study of Aging participant baseline characteristics

From: Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes

Characteristic Data available CU Data available MCI p value
Median (IQR) / N (%) Median (IQR) / N (%)
Age (years) 864 75.6 (67.0, 80.9) 131 81.4 (75.6, 85.3) <0.0001a
Male 864 479 (55.4%) 131 79 (60.3%) 0.2957b
Education (years) 864 15.0 (12.0, 16.0) 131 13.0 (12.0, 15.0) <0.0001a
≥ 1 APOE ε4 864 228 (26.4%) 131 45 (34.4%) 0.0570b
Plasma total tau (pg/mL) 864 2.53 (1.82, 3.30) 131 2.83 (1.94, 3.60) 0.0391a
Plasma NfL (pg/mL) 864 17.0 (11.8, 23.9) 131 23.1 (16.7, 32.5) <0.0001a
Body mass index (kg/m2) 860 27.5 (24.9, 31.0) 130 26.9 (23.6, 29.7) 0.0211a
Hypertension 864 571 (66.1%) 131 100 (76.3%) 0.0197b
Stroke 864 21 (2.4%) 131 10 (7.6%) 0.0014b
Myocardial infarction 864 96 (11.1%) 131 29 (22.1%) 0.0004b
Follow-up time (years) 864 6.2 (4.9, 7.5) 131 5.0 (2.7, 6.3) <0.0001a
Cognitive z-score
 Global 826 0.242 (−0.338, 0.830) 122 −1.325 (−1.953, −0.984) <0.0001a
 Memory 859 0.259 (−0.386, 0.835) 128 −1.470 (−1.902, −0.809) <0.0001a
 Language 844 0.243 (−0.400, 0.777) 126 −1.067 (−1.646, −0.390) <0.0001a
 Visuospatial ability 841 0.216 (−0.346, 0.761) 124 −1.140 (−2.068, −0.370) <0.0001a
 Attention 841 0.181 (−0.444, 0.761) 125 −0.765 (−1.565, −0.061) <0.0001a
Cortical thickness
 Frontal 583 2.325 (2.224, 2.411) 85 2.236 (2.160, 2.337) <0.0001a
 Parietal 582 2.629 (2.540, 2.729) 85 2.504 (2.406, 2.610) <0.0001a
 Temporal 583 2.076 (1.987, 2.169) 85 1.987 (1.924, 2.076) <0.0001a
 Occipital 583 1.879 (1.800, 1.958) 85 1.808 (1.753, 1.886) <0.0001a
Amyloid PET ≥ 1.48 SUVR 441 129 (29.3%) 59 39 (66.1%) <0.0001a
Hippocampal volume (cm3) 584 7.35 (6.84, 7.89) 85 6.85 (6.22, 7.21) <0.0001a
WMH volume (mm3) 341 0.005 (0.003, 0.011) 53 0.014 (0.008, 0.021) <0.0001a
Corpus callosum FA 369 0.643 (0.614, 0.662) 36 0.625 (0.565, 0.648) 0.0036a
Infarcts (total) 419 0 (0) 48 0 (0, 1) <0.0001a
  1. Hippocampal volume measures were adjusted for total intracranial volume
  2. APOE apolipoprotein E, FA fractional anisotropy, IQR interquartile range, MCI mild cognitive impairment, NfL neurofilament light, WMH white matter hyperintensity
  3. aKruskal Wallis rank sum test
  4. bPearson’s Chi-Square test