From: Plasma MCP-1 and changes on cognitive function in community-dwelling older adults
Period | Aβ42/40−a/MCP1−b n = 195 | Aβ42/40−/MCP1+ n = 85 | Aβ42/40+ /MCP1− n = 97 | Aβ42/40+ /MCP1+ n = 52 |
---|---|---|---|---|
Between-group difference (95% CI)c | Between-group difference (95% CI)c | Between-group difference (95% CI)c | Between-group difference (95% CI)c | |
Cognitive Composite Scored,n= 383 | ||||
 12 months | −0.09 (−0.12, −0.05) | −0.08 (−0.18, −0.03) | −0.24 (−0.39, −0.10)*** | −0.23 (−0.42, −0.04)** |
 24 months | −0.06 (−0.10, −0.03) | −0.08 (−0.19, 0.03) | −0.43 (−0.58, −0.27)*** | −0.28 (−0.48, −0.07)** |
 36 months | −0.16 (−0.20, −0.12) | −0.28 (−0.24, −0.00) | −0.39 (−0.56, −0.21)*** | −0.23 (−0.44, −0.01)* |
 48 months | −0.19 (−0.24, −0.15) | −0.13 (−0.26, −0.004) | −0.40 (−0.59, −0.21)*** | −0.41 (−0.65, −0.17)*** |
MMSE,n= 383 | ||||
 12 months | −0.12 (−0.26, 0.01) | −0.09 (−0.38, 0.21) | −0.45 (−0.87, −0.04)* | −0.50 (−1.03, 0.02) |
 24 months | −0.06 (−0.20, 0.08) | −0.21 (−0.52, 0.10) | −0.99 (−1.43, −0.55)*** | −0.36 (−0.91, 0.20) |
 36 months | −0.28 (−0.43, −0.13) | 0.01 (−0.33, 0.36) | −0.60 (−1.11, −0.08)* | −0.28 (−0.90, 0.35) |
 48 months | −0.21 (−0.37,−0.05) | −0.13 (−0.49, 0.23) | −0.69 (−1.23, −0.15)* | −0.66 (−1.35, 0.02) |
CDR sum of boxes,n= 383 | ||||
 12 months | 0.14 (0.08, 0.20) | 0.11 (−0.002, 0.22) | 0.08 (−0.08, 0.24) | 0.24 (0.04, 0.44)* |
 24 months | 0.13 (0.06, 0.20) | 0.17 (0.03, 0.31) | 0.13 (−0.07, 0.34) | 0.34 (0.08, 0.59)* |
 36 months | 0.23 (0.15, 0.31) | 0.12 (−0.06, 0.30) | 0.22 (−0.05, 0.48) | 0.31 (−0.01, 0.64) |
 48 months | 0.33 (0.23, 0.43) | 0.15 (−0.07, 0.36) | 0.37 (0.06, 0.68)* | 0.54 (0.15, 0.93)* |
Executive function composite scoree,n= 376 | ||||
 12 months | −0.02 (−0.05, 0.02) | −0.05 (−0.17, 0.06) | −0.32 (−0.49, −0.15)*** | −0.13 (−0.35, 0.08) |
 24 months | −0.04 (−0.08, −0.004) | −0.07 (−0.17, 0.06) | −0.34 (−0.52, −0.17)*** | −0.20 (−0.43, 0.02) |
 36 months | −0.10 (−0.14, −0.05) | −0.08 (−0.21, 0.06) | −0.39 (−0.58, −0.19)*** | −0.24 (−0.48, 0.01) |
 48 months | −0.12 (−0.17, −0.07) | −0.10 (−0.24, 0.05) | −0.41 (−0.62, −0.20)*** | −0.21 (−0.48, 0.06) |
Attention scoref,n= 383 | ||||
 12 months | −0.03 (−0.05, 0.00) | 0.00 (−0.09, 0.09) | −0.11 (−0.24, 0.02) | −0.13 (−0.29, 0.03) |
 24 months | −0.03 (−0.06, −0.01) | −0.01 (−0.11, 0.08) | −0.17 (−0.30, −0.03) | −0.21 (−0.38, −0.04)* |
 36 months | −0.10 (−0.13, −0.07) | −0.04 (−0.14, 0.06) | −0.12 (−0.27, 0.02) | −0.23 (−0.41, −0.05)* |
 48 months | −0.13 (−0.17, −0.10) | −0.04 (−0.14, 0.07) | −0.19 (−0.34, −0.04)* | −0.29 (−0.48, −0.09)** |