From: Impact of potential modifications to Alzheimer’s disease clinical trials in response to disruption by COVID-19: a simulation study
Trial modification
Linear mixed effects model: categorical time
Linear mixed effects model: continuous time
Student’s t test
Original t test (for reference)
Scenario 1
.42
.40
.19
.82
Scenario 2
.71
.67
.56
Scenario 3
.75
.64