Baseline [18F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer’s disease

Table 2 Linear mixed effects models assessing change on cognitive indices from baseline incorporating demographic, baseline cognitive, and imaging variables (using the WCG ROI and all participants). Partial regression coefficients (B), standard errors (SE), and t statistics are reported for each predictor; r² values are reported for each linear mixed effect model

WCG ROI	MMSE r² = 0.38		CDR-SB r² = 0.37		ADAS-Cog13 r² = 0.55		RBANS r² = 0.22
Covariate (units)	B (SE)	p	B (SE)	p	B (SE)	p	B (SE)	p
Baseline score (1 point)	0.07 (0.05)	0.217	0.20 (0.07)	*0.008*	0.07 (0.04)	0.157	−0.01 (0.06)	0.895
Age (10 years)	−0.68 (0.35)	0.056	0.76 (0.23)	*0.001*	1.35 (0.68)	*0.049*	−2.15 (1.17)	0.069
[¹⁸F]florbetapir (cortex; 0.1 SUVR)	−0.05 (0.15)	0.72	-0.09 (0.10)	0.380	0.03 (0.29)	0.926	0.11 (0.52)	0.846
MRI (cortical volume; cm³)	0.00 (0.01)	0.961	0.00 (0.00)	0.361	−0.02 (0.01)	0.107	−0.04 (0.02)	0.077
[¹⁸F]GTP1 (WCG; 0.1 SUVR)	−0.28 (0.12)	*0.015*	0.16 (0.08)	*0.043*	0.65 (0.23)	*0.006*	−1.62 (0.64)	*0.013*

Abbreviations: MMSE, Mini-Mental State Examination; CDR-SB, Clinical Dementia Rating Sum of Boxes; ADAS-Cog13, 13-item version of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status Total Index; WCG, whole cortical gray; SUVR, standardized uptake value ratio

ISSN: 1758-9193