Table 1 Clinical and MRI characteristics of cognitively impaired patients according to the evidence of Amyloid-beta accrual within the CNS (A+ vs A−) as provided by amyloid PET and CSF Ab levels
Demographic and conventional MRI variables | Subgroups | A− vs A+(p) | |
|---|---|---|---|
A− (n = 6) Mean ± SD | A+ (n = 17) Mean ± SD | ||
Age, years | 77.6 ± 3.8 | 75.3 ± 7.8 | 0.81 |
Gender, (F/M) | 2/4 | 7/10 | 0.68 |
MMSE, raw score | 21.8 ± 3.3 | 23.3 ± 4.6 | 0.57 |
Hachinski Ischaemic Score | 1.6 ± 1.2 | 0.7 ± 0.6 | 0.09 |
CSF Ab levels, (pg/mL) | 986 ± 384 | 530 ± 91 | < 0.001 |
WML volume, % of TIV | 0.15 ± 0.14 | 0.40 ± 0.32 | 0.049 |
NAWM volume, % of TIV | 24.47 ± 1.92 | 24.95 ± 1.72 | 0.48 |
GMF volume, % of TIV | 35.96 ± 4.15 | 36.68 ± 2.57 | 0.77 |