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Table 2 Multilevel univariable and multivariable logistic regressions predicting likelihood of disease progressiona

From: Prodromal frontotemporal dementia: clinical features and predictors of progression

  Univariable OR (95% CI) P value Multivariable OR (95% CI) P value
Age, years 1.00 (0.97 to 1.03) 0.927
Male sex (vs female) 0.72 (0.42 to 1.23) 0.225
Education, years 1.01 (0.94 to 1.09) 0.769
Genetic mutation (vs sporadic) 1.82 (0.86 to 3.85) 0.115
bvFTD (vs PPA) 1.30 (0.72 to 2.33) 0.387
Disease duration 1.02 (0.91 to 1.16) 0.711
Serum NfL, pg/mL 1.07 (1.03 to 1.11) < 0.001 1.08 (1.03 to 1.13) 0.003
MMSE score 0.93 (0.88 to 0.99) 0.020 0.79 (0.64 to 0.99) 0.040
FBI score 1.05 (1.02 to 1.08) 0.004 1.13 (1.03 to 1.24) 0.008
BADL lost 1.22 (0.77 to 1.90) 0.391
IADL lost 1.16 (0.95 to 1.41) 0.149
Digit span 0.84 (0.68 to 1.03) 0.098
Trail making test part A 1.00 (1.00 to 1.01) 0.029 1.00 (1.00 to 1.01) 0.362
Trail making test part B 1.00 (1.00 to 1.00) 0.015 1.00 (1.00 to 1.01) 0.485
  1. bvFTD Behavioural variant frontotemporal dementia, PPA Primary progressive aphasia, NfL Neurofilament light chain, MMSE Mini-Mental State Examination, FBI Frontal Behavioural Inventory
  2. aTransition to a higher global CDR plus NACC FTLD score at 1-year follow-up