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Table 4 The results of multiple linear regression analyses assessing the relationships between the serum zinc strata and the Aβ, AV-1451, AD-CM, and WMH status of cognitively normal older adults with no nutritional deficiencies

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

 

Stratified zinc level

 

Low

Medium

High

 

B (95% CI)

P

B (95% CI)

P

 

Aβ retention, SUVR

 Model 1

0.065 (0.011 to 0.120)

0.020

0.027 (− 0.026 to 0.081)

0.310

Reference

 Model 2

0.082 (0.025 to 0.138)

0.005

0.034 (−0.020 to 0.089)

0.217

Reference

AV-1451, SUVR

 Model 1

−0.021 (− 0.213 to 0.171)

0.827

−0.085 (00.296 to 0.127)

0.425

Reference

 Model 2

0.010 (−0.221 to 0.240)

0.933

−0.050 (− 0.313 to 0.212)

0.699

Reference

AD-CM, SUVR

 Model 1

−0.032 (− 0.074 to 0.010)

0.134

−0.016 (− 0.057 to 0.025)

0.436

Reference

 Model 2

−0.033 (− 0.078 to 0.013)

0.162

−0.010 (− 0.054 to 0.034)

0.668

Reference

WMH, cm3

 Model 1

− 0.078 (− 0.426 to 0.271)

0.660

−0.067 (− 0.408 to 0.275)

0.701

Reference

 Model 2

−0.215 (− 0.585 to 0.156)

0.254

−0.148 (− 0.503 to 0.207)

0.411

Reference

  1. Abbreviations: Aβ beta-amyloid, AD-CM Alzheimer’s disease signature cerebral glucose metabolism, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score, BMI body mass index, GDS geriatric depression scale
  2. The results of multiple linear regression analyses are presented with B coefficient values, 95% CI, and P value. Global Aβ retention and WMH values were used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates and model 2 included all potential covariates, including age, sex, education, APOE4 positivity, VRS, BMI, GDS score, annual income status, albumin, copper, calcium, iron, transferrin, and ceruloplasmin
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Alzheimer's Research & Therapy

ISSN: 1758-9193