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Table 4 The results of multiple linear regression analyses assessing the relationships between the serum zinc strata and the Aβ, AV-1451, AD-CM, and WMH status of cognitively normal older adults with no nutritional deficiencies

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

  Stratified zinc level
  Low Medium High
  B (95% CI) P B (95% CI) P  
Aβ retention, SUVR
 Model 1 0.065 (0.011 to 0.120) 0.020 0.027 (− 0.026 to 0.081) 0.310 Reference
 Model 2 0.082 (0.025 to 0.138) 0.005 0.034 (−0.020 to 0.089) 0.217 Reference
AV-1451, SUVR
 Model 1 −0.021 (− 0.213 to 0.171) 0.827 −0.085 (00.296 to 0.127) 0.425 Reference
 Model 2 0.010 (−0.221 to 0.240) 0.933 −0.050 (− 0.313 to 0.212) 0.699 Reference
AD-CM, SUVR
 Model 1 −0.032 (− 0.074 to 0.010) 0.134 −0.016 (− 0.057 to 0.025) 0.436 Reference
 Model 2 −0.033 (− 0.078 to 0.013) 0.162 −0.010 (− 0.054 to 0.034) 0.668 Reference
WMH, cm3
 Model 1 − 0.078 (− 0.426 to 0.271) 0.660 −0.067 (− 0.408 to 0.275) 0.701 Reference
 Model 2 −0.215 (− 0.585 to 0.156) 0.254 −0.148 (− 0.503 to 0.207) 0.411 Reference
  1. Abbreviations: beta-amyloid, AD-CM Alzheimer’s disease signature cerebral glucose metabolism, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score, BMI body mass index, GDS geriatric depression scale
  2. The results of multiple linear regression analyses are presented with B coefficient values, 95% CI, and P value. Global Aβ retention and WMH values were used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates and model 2 included all potential covariates, including age, sex, education, APOE4 positivity, VRS, BMI, GDS score, annual income status, albumin, copper, calcium, iron, transferrin, and ceruloplasmin