Serum zinc levels and in vivo beta-amyloid deposition in the human brain

Table 3 Results of multiple linear regression analyses for assessing the relationship between stratified zinc level and sub-regional Aβ deposition in cognitively normal individuals

	Frontal region		PC-PRC region		Lt. parietal region		Lt. temporal region
	B (95% CI)	P	B (95% CI)	P	B (95% CI)	P	B (95% CI)	P
Model 1^a
Low	0.100 (0.028 to 0.173)	0.007	0.128 (0.034 to 0.221)	0.008	0.1145 (0.035 to 0.192)	0.005	0.095 (0.028 to 0.161)	0.005
Medium	0.035 (− 0.035 to 0.105)	0.326	0.050 (− 0.040 to 0.141)	0.275	0.043 (− 0.032 to 0.119)	0.260	0.038 (−0.026 to 0.102)	0.243
High	Reference		Reference		Reference		Reference
Model 2^b
Low	0.116 (0.041 to 0.192)	0.003	0.148 (0.050 to 0.246)	0.003	0.131 (0.049 to 0.212)	0.002	0.112 (0.043 to 0.181)	0.002
Medium	0.031 (−0.040 to 0.101)	0.392	0.044 (− 0.048 to 0.135)	0.350	0.041 (−0.036 to 0.117)	0.297	0.037 (−0.027 to 0.101)	0.260
High	Reference		Reference		Reference		Reference

Abbreviations: Aβ beta-amyloid, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score, BMI body mass index, GDS geriatric depression scale
The results of multiple linear regression analyses are presented with B coefficient values, 95% CI, and P value. Global Aβ retention was used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates and model 2 included all potential covariates, including age, sex, education, APOE4 positivity, VRS, BMI, GDS score, annual income status, albumin, copper, calcium, iron, transferrin, and ceruloplasmin

ISSN: 1758-9193