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Table 3 Results of multiple linear regression analyses for assessing the relationship between stratified zinc level and sub-regional Aβ deposition in cognitively normal individuals

From: Serum zinc levels and in vivo beta-amyloid deposition in the human brain

  Frontal region PC-PRC region Lt. parietal region Lt. temporal region
B (95% CI) P B (95% CI) P B (95% CI) P B (95% CI) P
Model 1a
 Low 0.100 (0.028 to 0.173) 0.007 0.128 (0.034 to 0.221) 0.008 0.1145 (0.035 to 0.192) 0.005 0.095 (0.028 to 0.161) 0.005
 Medium 0.035 (− 0.035 to 0.105) 0.326 0.050 (− 0.040 to 0.141) 0.275 0.043 (− 0.032 to 0.119) 0.260 0.038 (−0.026 to 0.102) 0.243
 High Reference   Reference   Reference   Reference  
Model 2b
 Low 0.116 (0.041 to 0.192) 0.003 0.148 (0.050 to 0.246) 0.003 0.131 (0.049 to 0.212) 0.002 0.112 (0.043 to 0.181) 0.002
 Medium 0.031 (−0.040 to 0.101) 0.392 0.044 (− 0.048 to 0.135) 0.350 0.041 (−0.036 to 0.117) 0.297 0.037 (−0.027 to 0.101) 0.260
 High Reference   Reference   Reference   Reference  
  1. Abbreviations: beta-amyloid, CI confidence interval, APOE4 apolipoprotein E ε4 allele, VRS vascular risk score, BMI body mass index, GDS geriatric depression scale
  2. The results of multiple linear regression analyses are presented with B coefficient values, 95% CI, and P value. Global Aβ retention was used after natural log-transformation to achieve normal distribution. Model 1 did not include any covariates and model 2 included all potential covariates, including age, sex, education, APOE4 positivity, VRS, BMI, GDS score, annual income status, albumin, copper, calcium, iron, transferrin, and ceruloplasmin