The apolipoprotein receptor LRP3 compromises APP levels

Table 2 Expression of genes upregulated by full-length ApoER2 overexpression

Symbol	Gene name	Genomic location	Function	logFC	adj p
LRP3	Low-density lipoprotein receptor-related protein 3	19q13.11	Internalization of lipophilic molecules and/or signal transduction Precise role is unclear	0.48	0.047
LDLR	Low-density lipoprotein receptor	19p13.2	Mediates endocytosis of cholesterol-rich LDL	0.43	0.018
APOL1	apolipoprotein L, 1	22q12.3	Minor apoprotein component of HDL	1.28	0.003
INSIG1	Insulin-induced gene 1	7q36.3	Regulation of cholesterol cell concentration	0.72	0.001
DHCR24	24-Dehydrocholesterol reductase	1p32.3	Cholesterol metabolic process	0.35	0.008
MVK	Mevalonate kinase	12q24.11	Cholesterol metabolic process	0.33	0.019

Genes associated with lipid binding and transport, and cholesterol metabolism, whose transcripts were upregulated in ApoER2 overexpressing SH-SY5Y cells compared with control cells transfected with an empty vector. The expression of the genes was analyzed on DNA microarrays. The fold change (logFC) in gene expression between samples and controls, as well the adj p (p value adjusted for multiple testing) is indicated

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