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Table 2 Expression of genes upregulated by full-length ApoER2 overexpression

From: The apolipoprotein receptor LRP3 compromises APP levels

Symbol Gene name Genomic location Function logFC adj p
LRP3 Low-density lipoprotein receptor-related protein 3 19q13.11 Internalization of lipophilic molecules and/or signal transduction
Precise role is unclear
0.48 0.047
LDLR Low-density lipoprotein receptor 19p13.2 Mediates endocytosis of cholesterol-rich LDL 0.43 0.018
APOL1 apolipoprotein L, 1 22q12.3 Minor apoprotein component of HDL 1.28 0.003
INSIG1 Insulin-induced gene 1 7q36.3 Regulation of cholesterol cell concentration 0.72 0.001
DHCR24 24-Dehydrocholesterol reductase 1p32.3 Cholesterol metabolic process 0.35 0.008
MVK Mevalonate kinase 12q24.11 Cholesterol metabolic process   0.33 0.019
  1. Genes associated with lipid binding and transport, and cholesterol metabolism, whose transcripts were upregulated in ApoER2 overexpressing SH-SY5Y cells compared with control cells transfected with an empty vector. The expression of the genes was analyzed on DNA microarrays. The fold change (logFC) in gene expression between samples and controls, as well the adj p (p value adjusted for multiple testing) is indicated