Fig. 5
From: The apolipoprotein receptor LRP3 compromises APP levels
LRP3 co-immunoprecipitates with apoE and APP. a Representative immunofluorescence photomicrograph showing LRP3 and ApoER2 labeling in the same cells in a hippocampus slice of a MA subject. Neurons (large cells) show LRP3 and ApoER2 co-localization; in addition, oligodendroglia-like cells (thin arrows) also co-localize both antibodies. b Representative western blots showing immunoprecipitation of LRP3 and co-immunoprecipitation of reelin (no immunoprecipitation), apoE, and APP, from non-demented (ND) and Alzheimer’s disease (AD) extracts. T total input, B bound fraction, U unbound fraction, IPc bound fraction of the negative control