Table 3 Association of the expression levels of APH1B with neuroimaging biomarkers in ADNI and AddNeuroMed
Cohort | Neuroimaging biomarker | Transcript ID | T-value | P-value | FDR-corrected P-value |
|---|---|---|---|---|---|
ADNI | Entorhinal cortical thicknessa | 11720068_a_at | −2.85 | 4.50 × 10−3 | 2.25 × 10−2 |
11740603_a_at | −2.36 | 1.87 × 10−2 | 4.67 × 10− 2 | ||
11740602_s_at | −0.482 | 6.30 × 10−1 | 7.74 × 10− 1 | ||
11720067_a_at | 0.389 | 6.98 × 10−1 | 7.74 × 10− 1 | ||
11740601_a_at | 0.287 | 7.74 × 10−1 | 7.74 × 10− 1 | ||
Hippocampal volumea | 11720068_a_at | −2.69 | 7.40 × 10−3 | 3.70 × 10− 2 | |
11740603_a_at | −1.96 | 5.06 × 10−2 | 1.27 × 10− 1 | ||
11740602_s_at | −0.104 | 9.17 × 10−1 | 9.69 × 10− 1 | ||
11720067_a_at | −0.0969 | 9.23 × 10−1 | 9.69 × 10− 1 | ||
11740601_a_at | 0.0384 | 9.69 × 10−1 | 9.69 × 10− 1 | ||
Averaged cortical uptake of [18F] florbetapir PETb | 11720068_a_at | 3.15 | 1.71 × 10−3 | 8.54 × 10−3 | |
11740603_a_at | 2.64 | 8.51 × 10−3 | 2.13 × 10−2 | ||
11740602_s_at | 1.01 | 3.14 × 10−1 | 5.23 × 10−1 | ||
11740601_a_at | 0.765 | 4.45 × 10−1 | 5.56 × 10− 1 | ||
11720067_a_at | 0.121 | 9.04 × 10−1 | 9.04 × 10− 1 | ||
AddNeuroMed | Entorhinal cortical thicknessc | ILMN_1767816 | −0.761 | 4.47 × 10−1 | N/A |
Hippocampal volumec | ILMN_1767816 | 0.454 | 6.50 × 10−1 | N/A | |
ADNI and AddNeuroMed | Entorhinal cortical thicknessd | 11720068_a_at, ILMN_1767816 | −2.96 | 3.18 × 10−3 | N/A |
Hippocampal volumed | −1.93 | 5.91 × 10−2 | N/A |