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Table 3 Association of the expression levels of APH1B with neuroimaging biomarkers in ADNI and AddNeuroMed

From: Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer’s disease

Cohort Neuroimaging biomarker Transcript ID T-value P-value FDR-corrected P-value
ADNI Entorhinal cortical thicknessa 11720068_a_at −2.85 4.50 × 10−3 2.25 × 10−2
11740603_a_at −2.36 1.87 × 10−2 4.67 × 10− 2
11740602_s_at −0.482 6.30 × 10−1 7.74 × 10− 1
11720067_a_at 0.389 6.98 × 10−1 7.74 × 10− 1
11740601_a_at 0.287 7.74 × 10−1 7.74 × 10− 1
Hippocampal volumea 11720068_a_at −2.69 7.40 × 10−3 3.70 × 10− 2
11740603_a_at −1.96 5.06 × 10−2 1.27 × 10− 1
11740602_s_at −0.104 9.17 × 10−1 9.69 × 10− 1
11720067_a_at −0.0969 9.23 × 10−1 9.69 × 10− 1
11740601_a_at 0.0384 9.69 × 10−1 9.69 × 10− 1
Averaged cortical uptake of [18F] florbetapir PETb 11720068_a_at 3.15 1.71 × 10−3 8.54 × 10−3
11740603_a_at 2.64 8.51 × 10−3 2.13 × 10−2
11740602_s_at 1.01 3.14 × 10−1 5.23 × 10−1
11740601_a_at 0.765 4.45 × 10−1 5.56 × 10− 1
11720067_a_at 0.121 9.04 × 10−1 9.04 × 10− 1
AddNeuroMed Entorhinal cortical thicknessc ILMN_1767816 −0.761 4.47 × 10−1 N/A
Hippocampal volumec ILMN_1767816 0.454 6.50 × 10−1 N/A
ADNI and AddNeuroMed Entorhinal cortical thicknessd 11720068_a_at, ILMN_1767816 −2.96 3.18 × 10−3 N/A
Hippocampal volumed −1.93 5.91 × 10−2 N/A
  1. aData for 4 participants were unavailable (n = 657). T-value and P-values were obtained from linear regression analysis with adjustment of age, sex, intracranial volumes, and MRI field strength
  2. bData for 76 participants were unavailable (n = 585). T-value and P-values were obtained from linear regression analysis with adjustment of age and sex
  3. cData for 216 participants were unavailable (n = 458). T-value and P-values were obtained from linear regression analysis with adjustment of age, sex, and intracranial volumes
  4. dData for 220 participants were unavailable (n = 1115). T-value and P-values were obtained from a linear mixed model with adjustment of age, sex, and intracranial volumes
  5. Abbreviations: ADNI Alzheimer’s Disease Neuroimaging Initiative; FDR false discovery rate; Transcript ID transcript identifier of Affymetrix Human Genome U219 Array for ADNI and Illumina Human HT-12 v3 Expression BeadChips for AddNeuroMed