Table 1 Sample characteristics by regional amyloid stage
Full sample | Stage 0 | Stage I | Stage II | Stage III | Stage IV | Non-stageable | |
|---|---|---|---|---|---|---|---|
n | 220 | 183 | 8 | 7 | 10 | 8 | 4 |
Age, years (SD) | 61.4 (6.2) | 60.7 (6.2) | 67.5 (6.0) | 64.5 (3.5) | 63.7 (2.8) | 65.2 (4.8) | 64.7 (8.9) |
Sex, % female | 69% | 68% | 75% | 57% | 80% | 75% | 50% |
Education, years (SD) | 16.4 (2.6) | 16.4 (2.7) | 16.8 (1.8) | 17.6 (2.0) | 16.9 (2.6) | 15.9 (2.3) | 15.3 (2.2) |
APOE ε4 (%) | 34% | 29% | 40% | 83% | 60% | 71% | 0% |
Parental history of AD (%) | 73% | 71% | 43% | 86% | 90% | 100% | 75% |
Mean global 11C-PiB DVR | 1.03 | 0.98 | 1.08 | 1.19 | 1.32 | 1.46 | 1.07 |
Global 11C-PiB DVR > 1.08 | 33 (15%) | 3 (1.64%) | 3 (37.5%) | 7 (100%) | 10 (100%) | 8 (100%) | 2 (50%) |
MMSE | 29.3 (1.1) | 29.3 (1.1) | 29.7 (0.5) | 29.4 (0.8) | 29.4 (0.8) | 28.5 (2.7) | 29.8 (0.5) |
Delayed recall composite score | 0.04 (0.85) | 0.07 (0.81) | − 0.02 (0.83) | 0.23 (0.92) | − 0.27 (0.84) | − 0.59 (1.73) | 0.09 (0.96) |
Executive function composite score | − 0.06 (0.71) | − 0.01 (0.69) | 0.22 (0.25) | − 0.43 (1.30) | − 0.60 (0.56) | − 0.63 (0.54) | − 0.06 (0.52) |
Immediate learning composite score | 0.04 (0.82) | 0.06 (0.80) | 0.11 (0.71) | 0.21 (0.89) | − 0.27 (0.96) | − 0.27 (1.09) | 0.25 (1.11) |
PACC3 composite score | − 0.03 (0.78) | 0.00 (0.78) | 0.29 (0.55) | 0.07 (0.69) | − 0.59 (0.79) | − 0.43 (0.93) | − 0.05 (0.86) |