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Table 1 Sample characteristics by regional amyloid stage

From: In vivo staging of regional amyloid progression in healthy middle-aged to older people at risk of Alzheimer’s disease

  Full sample Stage 0 Stage I Stage II Stage III Stage IV Non-stageable
n 220 183 8 7 10 8 4
Age, years (SD) 61.4 (6.2) 60.7 (6.2) 67.5 (6.0) 64.5 (3.5) 63.7 (2.8) 65.2 (4.8) 64.7 (8.9)
Sex, % female 69% 68% 75% 57% 80% 75% 50%
Education, years (SD) 16.4 (2.6) 16.4 (2.7) 16.8 (1.8) 17.6 (2.0) 16.9 (2.6) 15.9 (2.3) 15.3 (2.2)
APOE ε4 (%) 34% 29% 40% 83% 60% 71% 0%
Parental history of AD (%) 73% 71% 43% 86% 90% 100% 75%
Mean global 11C-PiB DVR 1.03 0.98 1.08 1.19 1.32 1.46 1.07
Global 11C-PiB DVR > 1.08 33 (15%) 3 (1.64%) 3 (37.5%) 7 (100%) 10 (100%) 8 (100%) 2 (50%)
MMSE 29.3 (1.1) 29.3 (1.1) 29.7 (0.5) 29.4 (0.8) 29.4 (0.8) 28.5 (2.7) 29.8 (0.5)
Delayed recall composite score 0.04 (0.85) 0.07 (0.81) − 0.02 (0.83) 0.23 (0.92) − 0.27 (0.84) − 0.59 (1.73) 0.09 (0.96)
Executive function composite score − 0.06 (0.71) − 0.01 (0.69) 0.22 (0.25) − 0.43 (1.30) − 0.60 (0.56) − 0.63 (0.54) − 0.06 (0.52)
Immediate learning composite score 0.04 (0.82) 0.06 (0.80) 0.11 (0.71) 0.21 (0.89) − 0.27 (0.96) − 0.27 (1.09) 0.25 (1.11)
PACC3 composite score − 0.03 (0.78) 0.00 (0.78) 0.29 (0.55) 0.07 (0.69) − 0.59 (0.79) − 0.43 (0.93) − 0.05 (0.86)
  1. Values for age, years of education, MMSE and cognitive composite scores are presented as means with standard deviation in parentheses. Please note that individuals with missing values were excluded from this summary