Fig. 1

Regional amyloid progression model and the derived staging scheme with 4 stages. Brain renderings on the left illustrate the frequency of regional amyloid positivity (color scale) from black/blue (lowest) to yellow/red (highest), which was used as an indicator of temporal progression. In the resulting staging scheme on the right, incremental stages (I–IV) are defined by an involvement of higher numbered anatomic divisions (in red) in addition to the affected areas of the previous stage (blue)