Table 8 Genetic pathways targeted by three SCFAs
Alzheimer’s disease | GPCR ligand binding | Platelet activation, signaling, and aggregation |
|---|---|---|
Amyloids | Hemostasis | Platelet amyloid precursor protein pathway |
Caspase cascade in apoptosis | Immune system | Response to elevated platelet cytosolic Ca2+ |
Deregulation of CDK5 in Alzheimer’s disease | Inflammasomes | Signaling by GPCR |
G alpha (i) signaling events | Innate immune system | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
G alpha (q) signaling events | NFkB and MAP kinases activation mediated by TLR4 signaling repertoire | TLR4 signaling |
Gastrin-CREB signaling pathway via PKC and MAPK | NLRP3 inflammasome | Toll-like receptor cascades |
Glycosylation end product receptor signaling | Nucleotide-binding domain, leucine-rich repeat containing receptor (NLR) signaling pathways | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
Glypican 1 network | p75(NTR)-mediated signaling | TRAF6 mediated NF-kB activation |
GPCR downstream signaling | Peptide ligand-binding receptors | TRIF mediated TLR3 signaling |