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Table 8 Genetic pathways targeted by three SCFAs

From: Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

Alzheimer’s disease GPCR ligand binding Platelet activation, signaling, and aggregation
Amyloids Hemostasis Platelet amyloid precursor protein pathway
Caspase cascade in apoptosis Immune system Response to elevated platelet cytosolic Ca2+
Deregulation of CDK5 in Alzheimer’s disease Inflammasomes Signaling by GPCR
G alpha (i) signaling events Innate immune system TAK1 activates NFkB by phosphorylation and activation of IKKs complex
G alpha (q) signaling events NFkB and MAP kinases activation mediated by TLR4 signaling repertoire TLR4 signaling
Gastrin-CREB signaling pathway via PKC and MAPK NLRP3 inflammasome Toll-like receptor cascades
Glycosylation end product receptor signaling Nucleotide-binding domain, leucine-rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Glypican 1 network p75(NTR)-mediated signaling TRAF6 mediated NF-kB activation
GPCR downstream signaling Peptide ligand-binding receptors TRIF mediated TLR3 signaling