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Table 8 Genetic pathways targeted by three SCFAs

From: Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

Alzheimer’s disease

GPCR ligand binding

Platelet activation, signaling, and aggregation



Platelet amyloid precursor protein pathway

Caspase cascade in apoptosis

Immune system

Response to elevated platelet cytosolic Ca2+

Deregulation of CDK5 in Alzheimer’s disease


Signaling by GPCR

G alpha (i) signaling events

Innate immune system

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

G alpha (q) signaling events

NFkB and MAP kinases activation mediated by TLR4 signaling repertoire

TLR4 signaling

Gastrin-CREB signaling pathway via PKC and MAPK

NLRP3 inflammasome

Toll-like receptor cascades

Glycosylation end product receptor signaling

Nucleotide-binding domain, leucine-rich repeat containing receptor (NLR) signaling pathways

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Glypican 1 network

p75(NTR)-mediated signaling

TRAF6 mediated NF-kB activation

GPCR downstream signaling

Peptide ligand-binding receptors

TRIF mediated TLR3 signaling