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Table 6 Top 44 (top 20%) predicted microbial metabolites for the combined input “microgliosis,” “abnormal microglial cell physiology,” and “abnormal microglial cell morphology”

From: Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

R

Metabolite

R

Metabolite

R

Metabolite

R

Metabolite

1

Acetic acid

12

Ascorbic acid

23

Butyric acid

34

Sulfamethoxazole n1-glucuronide

2

Ethanol

13

Mannitol

24

Isopropyl alcohol

35

Salicyluric acid

3

d-Alanine

14

Epinephrine

25

Serotonin

36

Propionic acid

4

d-Glutamic acid

15

Methane

26

Folic acid

37

d-Proline

5

Hydrogen

16

Norepinephrine

37

Phenylethylamine

38

3-Hydroxydodecanoic acid

6

Dopamine

17

Gamma-aminobutyric acid

28

2-Phenylethanaminium

39

1-Butanol

7

d-Lactic acid

18

4-Hydroxybutyric acid

29

Phenol

40

3-Hydroxybutyric acid

8

l-Lactic acid

19

Oxoglutaric acid

30

Chenodeoxycholic acid 3-sulfate

41

Zeaxanthin

9

Hydroxypropionic acid

20

Glutaric acid

31

3,4-Dihydroxybenzeneacetic acid

42

Cis,cis-muconic acid

10

Acetaldehyde

21

Melatonin

32

Succinic acid

43

Trans-trans-muconic acid

11

Histamine

22

Trehalose

33

Muramic acid

44

Nndole