Fig. 5
Volume of distribution (VT) of [18F]THK-5317 obtained with Logan graphical analysis in 7, 13 and 21 months old female (A, B) and male (C, D) APP/Tau and ntg rats (female APP/Tau: 7 months: n = 7; 13 months: n = 7; 21 months: n = 6; female ntg (7–21 months): n = 15; male APP/Tau: 7 months: n = 7; 13 months: n = 10; 21 months: n = 8; male ntg (7–21 months): n = 12). Som.sen. Cortex = somatosensory cortex. *p < 0.05, **p < 0.01, ***p < 0.001; one-way ANOVA followed by Tukey’s multiple comparisons test