Table 1 Demographic and clinical characteristics

Age^a

64.3 (±6.8)

64.1 (±6.5)

64.1 (±6.7)

65.7 (±7.8)

65.3 (±6.1)

66.1 (±7.2)

Sex M/F ^b

37/50

14/17

19/18

16/14

18/21

22/25

Education (years)^a

17.3 (±1.9)

17.2 (±2.9)

15.3 (±3.7)

17.2 (±3.5)

16.9 (±4.1)

15.9 (±4.2)

MMSE^a

29.5 (±0.7)

24.8 (±5.1) *

24.1 (±4.6) *

24.9 (±5.9) *

23.4 (±5.8) *

24.8 (±3.9) *

MoCA ^a

28.1 (±1.6)

19.1 (±4.2) *

17.6 (±6.9) *

20.5 (±6.3) *

19.1 (±6.4) *

21.1 (±4.3) *

CDR global %

0=100

0.5=0

1=0

2=0

3=0

0=3.2

0.5=29.1

1=41.9

2=25.8

3=0

0=0

0.5=51.4

1=29.7

2=18.9

3=0

0=10

0.5=43.3

1=30

2=16.7

3=0

0=2.9

0.5=48.6 1=34.3

2=11.3

3=2.9

0=9.1

0.5=45.4

1=36.4

2=9.1

3=0

CDR-SB^a

0

5.4 (±3.1) *

3.65 (±2.5) *

2.9 (±1.6)

3.8 (±3.2) *

4.1 (±3.1) *

UPDRS^a

0.1 (±0.5)

2.7 (±3.1) *

4.6 (±5.5) *

8.1 (±9.6) *

33.3 (±15.1) *#

35.0 (±18.2) *#

Training cohort

HS = 58

bvFTD = 15

svPPA = 21

nfvPPA = 17

CBS = 24

PSP-RS = 32

Age^a

64.1 (7.1)

64.5 (6.4)

64.5 (6.4)

65.5 (7.1)

66.2 (6.2)

66.5 (6.9)

Sex M/F^b

24/34

7/8

11/10

9/8

11/13

15/17

Education (years)^a

17.3 (1.8)

17.4 (3.5)

15.7 (3.9)

16.7 (4.3)

17.5 (4.3)

14.9 (4.2)

MMSE^a

29.4 (0.8)

24.2 (3.9) *

23.2 (4.6) *

25.5 (4.6) *

23.8 (5.7) *

25.1 (3.5) *

MoCA^a

27.9 (1.7)

18.7 (3.5) *

18.5 (5.1) *

19.3 (7.2) *

19.3 (6.1) *

21.6 (2.9) *

CDR global %

0=100

0.5=0

1=0

2=0

3=0

0=0

0.5=26.7

1=46.7

2=26.7

3=0

0=0

0.5=52.4

1=28.6

2=19

3=0

0=5.9

0.5=47.1

1=29.4

2=17.6

3=0

0=5

0.5=50

1=35

2=10

3=0

0=10.3

0.5=48.3

1=34.5

2=6.9

3=0

CDR-SB^a

0

5.5 (±3.5) *

4 (±2.2) *

2.8 (±1.2)

3.4 (±2.1) *

4.2 (±3.1) *

UPDRS^a

0 (0)

2.7 (±3.2) *

4.1 (±4.8) *

7.2 (±8.1) *

33.1 (±11.1) *#

35.3 (±19.8) *#

Test cohort

HS = 29

bvFTD = 16

svPPA = 16

nfvPPA = 13

CBS = 15

PSP-RS = 15

Age^a

64.7 (±5.6)

63.6 (±6.4)

63.6 (±7.2)

66.2 (±6.8)

64.4 (±6.3)

65.6 (±8.3)

Sex M/F^b

13/16

7/9

8/8

7/6

7/8

7/8

Education (years)^a

17.4 (±1.8)

17.0 (±2.7)

14.8 (±3.3)

18.2 (±1.7)

15.5 (±3.1)

17.6 (±3.5)

MMSE^a

29.5 (±0.6)

25.2 (±5.9) *

25.4 (±4.4) *

23.6 (±8.3) *

22.7 (±6.4) *

24.2 (±4.9) *

MoCA^a

28.5 (±1.4)

19.4 (±4.9) *

16.4 (±9.1) *

22.4 (±4.1) *

18.4 (±7.8) *

19.6 (±6.1) *

CDR global %

0=100

0.5=0

1=0

2=0

3=0

0=6.25

0.5=31.25

1=37.5

2=25

3=0

0=0

0.5=50

1=31.3

2=18.7

3=0

0=15.4

0.5=38.5

1=30.7

2=15.4

3=0

0=0

0.5=46.6 1=33.3

2=13.3

3=6.7

0=6.7

0.5=40

1=40

2=13.3

3=0

CDR-SB^a

0

5.3 (±3.9) *

3.3 (±2.7) *

2.8 (±2.4)

4.5 (±4.2) *

3.8 (±2.8) *

UPDRS ^a

0.4 (±0.9)

2.7 (±3.1) *

5.3 (±6.39) *

9.7 (±10.2) *

33.7 (±18.2) *#

34.5 (±15.5) *#