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Table 1 Demographic and clinical characteristics

From: Intracortical diffusion tensor imaging signature of microstructural changes in frontotemporal lobar degeneration

Entire cohort HS = 87 bvFTD = 31 svPPA = 37 nfvPPA = 30 CBS = 39 PSP-RS = 47
Agea 64.3 (±6.8) 64.1 (±6.5) 64.1 (±6.7) 65.7 (±7.8) 65.3 (±6.1) 66.1 (±7.2)
Sex M/F b 37/50 14/17 19/18 16/14 18/21 22/25
Education (years)a 17.3 (±1.9) 17.2 (±2.9) 15.3 (±3.7) 17.2 (±3.5) 16.9 (±4.1) 15.9 (±4.2)
MMSEa 29.5 (±0.7) 24.8 (±5.1) * 24.1 (±4.6) * 24.9 (±5.9) * 23.4 (±5.8) * 24.8 (±3.9) *
MoCA a 28.1 (±1.6) 19.1 (±4.2) * 17.6 (±6.9) * 20.5 (±6.3) * 19.1 (±6.4) * 21.1 (±4.3) *
CDR global % 0=100
0.5=0
1=0
2=0
3=0
0=3.2
0.5=29.1
1=41.9
2=25.8
3=0
0=0
0.5=51.4
1=29.7
2=18.9
3=0
0=10
0.5=43.3
1=30
2=16.7
3=0
0=2.9
0.5=48.6 1=34.3
2=11.3
3=2.9
0=9.1
0.5=45.4
1=36.4
2=9.1
3=0
CDR-SBa 0 5.4 (±3.1) * 3.65 (±2.5) * 2.9 (±1.6) 3.8 (±3.2) * 4.1 (±3.1) *
UPDRSa 0.1 (±0.5) 2.7 (±3.1) * 4.6 (±5.5) * 8.1 (±9.6) * 33.3 (±15.1) *# 35.0 (±18.2) *#
Training cohort HS = 58 bvFTD = 15 svPPA = 21 nfvPPA = 17 CBS = 24 PSP-RS = 32
Agea 64.1 (7.1) 64.5 (6.4) 64.5 (6.4) 65.5 (7.1) 66.2 (6.2) 66.5 (6.9)
Sex M/Fb 24/34 7/8 11/10 9/8 11/13 15/17
Education (years)a 17.3 (1.8) 17.4 (3.5) 15.7 (3.9) 16.7 (4.3) 17.5 (4.3) 14.9 (4.2)
MMSEa 29.4 (0.8) 24.2 (3.9) * 23.2 (4.6) * 25.5 (4.6) * 23.8 (5.7) * 25.1 (3.5) *
MoCAa 27.9 (1.7) 18.7 (3.5) * 18.5 (5.1) * 19.3 (7.2) * 19.3 (6.1) * 21.6 (2.9) *
CDR global % 0=100
0.5=0
1=0
2=0
3=0
0=0
0.5=26.7
1=46.7
2=26.7
3=0
0=0
0.5=52.4
1=28.6
2=19
3=0
0=5.9
0.5=47.1
1=29.4
2=17.6
3=0
0=5
0.5=50
1=35
2=10
3=0
0=10.3
0.5=48.3
1=34.5
2=6.9
3=0
CDR-SBa 0 5.5 (±3.5) * 4 (±2.2) * 2.8 (±1.2) 3.4 (±2.1) * 4.2 (±3.1) *
UPDRSa 0 (0) 2.7 (±3.2) * 4.1 (±4.8) * 7.2 (±8.1) * 33.1 (±11.1) *# 35.3 (±19.8) *#
Test cohort HS = 29 bvFTD = 16 svPPA = 16 nfvPPA = 13 CBS = 15 PSP-RS = 15
Agea 64.7 (±5.6) 63.6 (±6.4) 63.6 (±7.2) 66.2 (±6.8) 64.4 (±6.3) 65.6 (±8.3)
Sex M/Fb 13/16 7/9 8/8 7/6 7/8 7/8
Education (years)a 17.4 (±1.8) 17.0 (±2.7) 14.8 (±3.3) 18.2 (±1.7) 15.5 (±3.1) 17.6 (±3.5)
MMSEa 29.5 (±0.6) 25.2 (±5.9) * 25.4 (±4.4) * 23.6 (±8.3) * 22.7 (±6.4) * 24.2 (±4.9) *
MoCAa 28.5 (±1.4) 19.4 (±4.9) * 16.4 (±9.1) * 22.4 (±4.1) * 18.4 (±7.8) * 19.6 (±6.1) *
CDR global % 0=100
0.5=0
1=0
2=0
3=0
0=6.25
0.5=31.25
1=37.5
2=25
3=0
0=0
0.5=50
1=31.3
2=18.7
3=0
0=15.4
0.5=38.5
1=30.7
2=15.4
3=0
0=0
0.5=46.6 1=33.3
2=13.3
3=6.7
0=6.7
0.5=40
1=40
2=13.3
3=0
CDR-SBa 0 5.3 (±3.9) * 3.3 (±2.7) * 2.8 (±2.4) 4.5 (±4.2) * 3.8 (±2.8) *
UPDRS a 0.4 (±0.9) 2.7 (±3.1) * 5.3 (±6.39) * 9.7 (±10.2) * 33.7 (±18.2) *# 34.5 (±15.5) *#
  1. MMSE Mini-Mental State Examination; MoCA Montreal Cognitive Assessment; CDR Clinical Dementia Rating scale, global score; CDR-SB Clinical Dementia Rating scale, sum of boxes; UPDRS Unified Parkinson’s Disease Rating Scale
  2. aANOVA
  3. bChi-square
  4. *P < 0.05 patient group versus HS, FDR corrected; #P < 0.05 patient group versus bvFTD, svPPA, nfvPPA, FDR corrected